2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate

Base Information

Chemical Name:2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate
CAS No.:1372608-86-0
Molecular Formula:C₁₅H₁₂FN₃O₂
Molecular Weight:285.278
Hs Code.:

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Chemical Property of 2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate

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Technology Process of 2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate

There total 5 articles about 2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 64-18-6
formic acid

: 1093981-22-6
2-azido-1-(4-fluorobenzyl)-1H-benzo[d]imidazole

: 1372608-86-0
2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h; Irradiation;
DOI:10.1002/ejoc.201101711

Reference yield: 5.0%

: 1093981-22-6
2-azido-1-(4-fluorobenzyl)-1H-benzo[d]imidazole

: 1372608-86-0
2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h; Irradiation; Inert atmosphere;
DOI:10.1002/ejoc.201101711

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1372608-86-0
2-amino-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-6yl formate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 14 h / 0 - 65 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 3.5 h / -78 - 20 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 20 °C / Irradiation

With n-butyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/ejoc.201101711