4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine

Base Information Edit

Chemical Name:4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine
CAS No.:312584-53-5
Molecular Formula:C13H9 Cl N2 O S
Molecular Weight:276.746
Hs Code.:2934999090
European Community (EC) Number:691-880-0
DSSTox Substance ID:DTXSID001325651
ChEMBL ID:CHEMBL586309
Mol file:312584-53-5.mol

Synonyms:312584-53-5;4-chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine;TCMDC-123805;THIENO[2,3-D]PYRIMIDINE,4-CHLORO-5-(4-METHOXYPHENYL)-;4-CHLORO-5-(4-METHOXY-PHENYL)-THIENO[2,3-D]-PYRIMIDINE;4-Chloro-5-(4-methoxyphenyl)-thieno[2,3-d]pyrimidine;ChemDiv2_001369;MLS000765103;CHEMBL586309;SCHEMBL2253337;DTXSID001325651;HMS1372O05;HMS2716H08;MFCD01831011;AKOS000116981;CCG-112799;SMR000288508;EN300-07406;J-018304;Z56974900;F0920-2804

Suppliers and Price of 4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine 95%
1g
$ 407.00

American Custom Chemicals Corporation
4-CHLORO-5-(4-METHOXYPHENYL)THIENO[2,3-D]PYRIMIDINE 95.00%
5G
$ 1548.26

American Custom Chemicals Corporation
4-CHLORO-5-(4-METHOXYPHENYL)THIENO[2,3-D]PYRIMIDINE 95.00%
1G
$ 852.55

Alfa Aesar
4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine, 96%
5g
$ 146.00

Alfa Aesar
4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine, 96%
1g
$ 44.60

Alfa Aesar
4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine, 96%
250mg
$ 16.10

AK Scientific
4-Chloro-5-(4-methoxyphenyl)-thieno[2,3-d]pyrimidine
250mg
$ 201.00

Total 4 raw suppliers

Chemical Property of 4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine Edit

Chemical Property:

Melting Point:166-168℃
Boiling Point:450.0±45.0 °C(Predicted)
PKA:0.46±0.40(Predicted)
PSA：63.25000
Density:1.378±0.06 g/cm3(Predicted)
LogP:4.02030
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:276.0124118
Heavy Atom Count:18
Complexity:286

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)Cl

Technology Process of 4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine

There total 7 articles about 4-Chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 17537-76-7
5-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

: 312584-53-5
4-chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine

Guidance literature:: With N,N-dimethyl-formamide; trichlorophosphate; at 110 ℃; for 6h;
DOI:10.1021/acs.jmedchem.8b01391

Reference yield:

: 17537-76-7
5-(4-methoxy-phenyl)-3H-thieno[2,3-d]pyrimidin-4-one

: 312584-53-5
4-chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 312584-53-5
4-chloro-5-(4-methoxyphenyl)thieno[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: morpholine; sulfur / ethanol / 16 h / 80 °C

2: 4 h / 160 °C

3: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C

With morpholine; thionyl chloride; sulfur; N,N-dimethyl-formamide; In ethanol;