446273-59-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-4-bromo-6-chloropyridazine is used as a key intermediate in the synthesis of novel potent imidazo[1,2-b]pyridazine PDE10A inhibitors. These inhibitors are being developed for the treatment of various neurological disorders, such as schizophrenia and Huntington's disease, due to their ability to modulate the activity of phosphodiesterase 10A (PDE10A), an enzyme involved in signal transduction pathways in the brain.
3-Amino-4-bromo-6-chloropyridazine's unique structural features, including the presence of a bromine and chlorine atom, make it a valuable building block for the development of new therapeutic agents with improved potency, selectivity, and pharmacokinetic properties. Its use in the pharmaceutical industry is focused on the design and synthesis of innovative drugs that can address unmet medical needs and improve the quality of life for patients suffering from neurological conditions.

InChI:InChI=1/C4H3BrClN3/c5-2-1-3(6)8-9-4(2)7/h1H,(H2,7,9)

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 

Downstream Products

• 808770-39-0 6-chloro-4-methoxypyridazin-3-amine 
• 933034-89-0 8-bromo-6-chloro-imidazo[1,2-b]pyridazine hydrochloride 
• 1040376-43-9 6-chloro-4-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazin-3-ylamine 
• 933041-13-5 4-bromo-6-chloro-pyridazin-3(2H)-one 
• 933190-51-3 8-bromo-6-chloro-imidazo[1,2-b]pyridazine 
• 1313014-24-2 6-Chloro-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-8-morpholin-4-yl-imidazo[1,2-b] pyridazine 
• 1466574-40-2 6-chloro-4-(4-fluoro-2-methoxyphenyl)pyridazin-3-ylamine 
• 1207625-15-7 6-chloro-4-((trimethylsilyl)ethynyl)pyridazin-3-amine 
• 1346818-42-5 6-chloro-4-[(R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]pyridazin-3-ylamine 
• 1161847-29-5 6,8-dichloro-imidazo[1,2-b]pyridazine 
• 1298031-95-4 8-bromo-6-chloro-2-cyclopropylimidazo[1,2-b]pyridazine 
• 1298031-93-2 6,8-dichloro-2-methylimidazo[1,2-b]pyridazine 
• 1298031-94-3 8-bromo-6-chloro-2-methylimidazo[1,2-b]pyridazine 
• 1232039-56-3 C₁₂H₆BrCl₂N₃ 

Relevant academic research and scientific papers

Synthesis of Pyridazine-Based α-Helix Mimetics

A versatile synthesis of pyridazine-based small molecule α-helix mimetics (A) is presented. Modular C-C, C-N, and C-O bond-forming reactions allow for the inclusion of a variety of aliphatic, basic, aromatic, and heteroaromatic side chain moieties. This robust synthesis is suitable for the preparation of small pyridazine-based libraries.

Heterocyclic compound as well as pharmaceutical composition, preparation method, intermediate and application thereof

The invention discloses a heterocyclic compound as well as a pharmaceutical composition, a preparation method, an intermediate and application thereof. The structure of the heterocyclic compound is shown as a formula I, and the heterocyclic compound has CDK7 inhibitory activity and can be used for treating diseases such as tumors.

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition. Non-limiting examples of such diseases, disorders, or conditions include: (i) cardiovascular disease; (ii) metabolic disorders; (iii) diseases, disorders, and conditions associated with vascular pathology; and (iv) organ failure; (v) diseases, disorders, and conditions associated with infections (e.g., microbial infections); and (vi) diseases, disorders, or conditions that are sequela or comorbid with any of the foregoing or any disclosed herein. More particular non-limiting examples of such diseases, disorders, or conditions include pulmonary hypertension (e.g., PAH); heart failure; type II diabetes; renal failure; sepsis; and systemic hypertension.

PROCESS FOR THE PREPRATION OF 7-(4,7-DIAZASPIRO[2.5]OCTAN-7-YL)-2-(2,8-DIMETHYLIMIDAZO[1,2-B]PYRIDAZIN-6-YL)PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES

The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)pyrido[l,2-a]pyrimidin-4-one derivatives useful pharmaceutically active compounds.

PYRIDAZINE DERIVATIVES AS SMARCA2/4 DEGRADERS

The present invention provides pyridazine derivatives of formula (I), which are therapeutically useful as SMARCA2/4 degraders. These compounds are useful in the treatment and/or prevention of diseases or disorders dependent upon SMARCA2/4 in a mammal. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the pyridazine derivatives of formula (I) or a pharmaceutically acceptable salt, or a stereoisomer thereof.

Design and Evaluation of Heterobivalent PAR1-PAR2 Ligands as Antagonists of Calcium Mobilization

A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the subtypes PAR1 and PAR2. Modified versions of the PAR1 antagonist RWJ-58259 containing alkyne adapters were connected via cycloaddition reactions to azide-capped polyethylene glycol (PEG) spacers attached to imidazopyridazine-based PAR2 antagonists. Initial studies of the PAR1-PAR2 antagonists indicated that they inhibited G alpha q-mediated calcium mobilization in endothelial and cancer cells driven by both PAR1 and PAR2 agonists. Compounds of this novel class hold promise for the prevention of restenosis, cancer cell metastasis, and other proliferative disorders.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.