2,5,8,11,14,17-Hexaoxanonadecan-19-amine

Base Information

• Chemical Name: 2,5,8,11,14,17-Hexaoxanonadecan-19-amine
• CAS No.: 184357-46-8
• Molecular Formula: C13H29NO6
• Molecular Weight: 295.376
• Mol file: 184357-46-8.mol

Synonyms:methyletherhexaethyleneglycol amine;3,6,9,12,15,18-HEXAOXANONADECAN-1-AMINE;1-amino-3,6,9,12,15,18-hexaoxanonadecane;

Chemical Property of 2,5,8,11,14,17-Hexaoxanonadecan-19-amine

Chemical Property:

• Boiling Point: 368.5±37.0 °C(Predicted)
• PKA: 8.74±0.10(Predicted)
• PSA: 81.40000
• Density: 1.036
• LogP: 0.37480
• Storage Temp.: -20°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5,8,11,14,17-Hexaoxanonadecan-19-amine min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG6-amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Technology Process of 2,5,8,11,14,17-Hexaoxanonadecan-19-amine

There total 10 articles about 2,5,8,11,14,17-Hexaoxanonadecan-19-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-azido-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane (1043884-49-6,89485-61-0) → 1-amino-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane (184357-46-8,80506-64-5,869718-87-6)

Guidance literature:

1-azido-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 5h;

With water; In tetrahydrofuran; at 80 ℃;

Reference yield: 54.0%

ammonium hydroxide (1336-21-6) + 1-phthalimidohexaethylene glycol monomethyl ether → 1-amino-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane (184357-46-8,80506-64-5,869718-87-6)

Guidance literature:

With hydrogenchloride; potassium hydroxide; hydrazine; In ethanol; chloroform;

Reference yield: 45.0%

sodium azide + 2,5,8,11,14,17-hexaoxanonadecan-19-yl 4-methylbenzenesulfonate (155887-96-0,58320-73-3) → 1-amino-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane (184357-46-8,80506-64-5,869718-87-6)

Guidance literature:

sodium azide; 2,5,8,11,14,17-hexaoxanonadecan-19-yl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; for 12h; Reflux;

With palladium on activated charcoal; hydrogen; In ethanol; for 4h; under 2585.81 Torr;

upstream raw materials:

1-azido-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane

hexaethylene glycol monomethyl ether

2,5,8,11,14,17-hexaoxanonadecan-19-yl 4-methylbenzenesulfonate

pentaethylene glycol

Refernces

• 1、 Wang, Qiuhua,Zhong, Yulong,Miller, Daniel P.,Lu, Xiaoxing,Tang, Quan,Lu, Zhong-Lin,Zurek, Eva,Liu, Rui,Gong, Bing. "Self-Assembly and Molecular Recognition in Water: Tubular Stacking and Guest-Templated Discrete Assembly of Water-Soluble, Shape-Persistent Macrocycles". supporting information. p. 2915 - 2924. Retrieved 2020/02/04.
• 2、 -. "IN VITRO COMPOSITIONS COMPRISING HUMAN SAMPLE AND AMYLOID TARGETING AGENT". . . Retrieved 2016/06/01.