METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE

Base Information

• Chemical Name: METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE
• CAS No.: 64321-95-5
• Molecular Formula: C9H8F3NO2
• Molecular Weight: 219.163
• Hs Code.: 2922499990
• Mol file: 64321-95-5.mol

Synonyms:Methyl 2-amino-3-(trifluoromethyl)benzoate;

Chemical Property of METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE

Chemical Property:

• Vapor Pressure: 0.0111mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 262.1 °C at 760 mmHg
• Flash Point: 112.3 °C
• PSA: 52.32000
• Density: 1.343 g/cm³
• LogP: 2.65540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% purity ^*data from raw suppliers

Methyl2-Amino-3-(trifluoromethyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE

There total 7 articles about METHYL 2-AMINO-3-TRIFLUOROMETHYLBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-3-(trifluoromethyl)benzoic acid (313-12-2) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-amino-3-trifluoromethyl-benzoate (64321-95-5)

Guidance literature:

With methanol; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield: 74.88%

methanol (67-56-1) + 2-amino-3-(trifluoromethyl)benzoic acid (313-12-2) → methyl 2-amino-3-trifluoromethyl-benzoate (64321-95-5)

Guidance literature:

With sulfuric acid; at 0 - 80 ℃; for 16h;

Reference yield:

7-trifluoromethylisatin (391-12-8) → methyl 2-amino-3-trifluoromethyl-benzoate (64321-95-5)

Guidance literature:

With dihydrogen peroxide; sodium methylate; In methanol; water;

upstream raw materials:

methanol

7-trifluoromethylisatin

2-amino-3-(trifluoromethyl)benzoic acid

Togni's reagent II

Downstream raw materials:

2-bromo-3-(trifluoromethyl)benzoic acid

methyl 2-bromo-3-(trifluoromethyl)benzoate

Refernces

• 1、 -. "INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA". Paragraph 0156. . Retrieved 2018/04/20.
• 2、 -. "Preparation of alkyl anthranilates". . . Retrieved 2008/06/13.