4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

Base Information

Chemical Name:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide
CAS No.:220996-86-1
Molecular Formula:C₁₈H₂₃BrF₃NO₄
Molecular Weight:454.284
Hs Code.:

Synonyms:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

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Chemical Property of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

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Technology Process of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

There total 7 articles about 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 220996-85-0
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl alcohol

: 220996-86-1
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In diethyl ether;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 558-13-4
carbon tetrabromide

: 220996-85-0
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl alcohol

: 220996-86-1
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

Guidance literature:: With triphenylphosphine; In ethyl acetate;

Reference yield:

: 220996-81-6
(4-bromo-2-(trifluoromethoxy)phenyl)methanol

: 220996-86-1
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)benzyl bromide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

2: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

3: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

4: 95 percent / Bu₄NF / tetrahydrofuran

5: 85 percent / CBr₄, Ph₃P / diethyl ether

With dmap; n-butyllithium; Trimethyl borate; carbon tetrabromide; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(99)00181-X