Chemical Property of VEGF receptor tyrosine kinase inhibitor III
Chemical Property:
- Melting Point:231-232°C
- Boiling Point:545.6±50.0 °C(Predicted)
- PKA:13.08±0.70(Predicted)
- PSA：98.09000
- Density:1.321
- LogP:4.90160
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble3mg/mL, clear (warmed)
- XLogP3:3.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:7
- Exact Mass:416.1251329
- Heavy Atom Count:29
- Complexity:529
- Purity/Quality:
-
99%, *data from raw suppliers
KRN633 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
-
Useful:
- Canonical SMILES:CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl
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Uses
KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM. KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
