2-amino-3,5-difluorobenzoic acid

Base Information

• Chemical Name: 2-amino-3,5-difluorobenzoic acid
• CAS No.: 126674-78-0
• Molecular Formula: C7H5F2NO2
• Molecular Weight: 173.119
• Hs Code.: 2922499990
• Mol file: 126674-78-0.mol

Synonyms:2-Amino-3,5-difluorobenzoic acid;

Chemical Property of 2-amino-3,5-difluorobenzoic acid

Chemical Property:

• Appearance/Colour: white crystal powder
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 291.793 °C at 760 mmHg
• PKA: 4.26±0.10(Predicted)
• Flash Point: 130.272 °C
• PSA: 63.32000
• Density: 1.537 g/cm³
• LogP: 1.82640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-amino-3,5-difluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-3,5-difluorobenzoic acid

There total 3 articles about 2-amino-3,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-difluoro-2-nitrobenzoic acid (331765-71-0) → 2-amino-3,5-difluorobenzoic acid (126674-78-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 4h; under 37503.8 Torr;

Reference yield:

5,7-difluoroindoline-2,3-dione (116570-41-3) → 2-amino-3,5-difluorobenzoic acid (126674-78-0)

Guidance literature:

5,7-difluoroindoline-2,3-dione; With sulfuric acid; dihydrogen peroxide; acetic acid; at 75 - 100 ℃; for 0.333333h;

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.333333h; Further stages.;

DOI:10.1016/j.bmc.2007.12.017

Reference yield:

3,5-difluorobenzoic acid (455-40-3) → 2-amino-3,5-difluorobenzoic acid (126674-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 1 h / 20 °C

1.2: 20 - 45 °C

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / 37503.8 Torr

With sulfuric acid; palladium 10% on activated carbon; hydrogen; In ethyl acetate;

upstream raw materials:

3,5-difluoro-2-nitrobenzoic acid

5,7-difluoroindoline-2,3-dione

3,5-difluorobenzoic acid

Downstream raw materials:

C₈H₇F₂NO₂

2-amino-3,5-difluoro-benzamide

Refernces

• 1、 Clark, David A.,Lahm, George P.,Smith, Ben K.,Barry, James D.,Clagg, Don G.. "Synthesis of insecticidal fluorinated anthranilic diamides". . p. 3163 - 3170. Retrieved 2008/09/20.