4-CHLORO-6-METHYL-NICOTINIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-CHLORO-6-METHYL-NICOTINIC ACID METHYL ESTER
• CAS No.: 886372-05-0
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Hs Code.: 2933399090
• Mol file: 886372-05-0.mol

Synonyms:METHYL 4-CHLORO-6-METHYLNICOTINATE;4-chloro-6-methyl-nicotinic acid methyl ester;QC-9084;4-Chloro-6-methyl-3-pyridinecarboxylic acid methyl ester;

Chemical Property of 4-CHLORO-6-METHYL-NICOTINIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 242.7 °C at 760 mmHg
• Flash Point: 100.6 °C
• PSA: 39.19000
• Density: 1.247 g/cm³
• LogP: 1.83000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl4-chloro-6-methylpyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-6-METHYL-NICOTINIC ACID METHYL ESTER

There total 8 articles about 4-CHLORO-6-METHYL-NICOTINIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

methanol (67-56-1) + 4‐chloro‐6‐methylpyridine‐3‐carbonyl chloride (1005515-30-9) → methyl 4-chloro-6-methylpyridine-3-carboxylate (886372-05-0)

Guidance literature:

In tetrahydrofuran; at 100 ℃;

Reference yield: 94.1%

4‐chloro‐6‐methylpyridine‐3‐carbonyl chloride (1005515-30-9) → methyl 4-chloro-6-methylpyridine-3-carboxylate (886372-05-0)

Guidance literature:

In tetrahydrofuran; methanol; at 20 - 100 ℃; for 2h;

Reference yield: 91.0%

methanol (67-56-1) + 4-hydroxy-6-methylnicotinic acid (67367-33-3) → methyl 4-chloro-6-methylpyridine-3-carboxylate (886372-05-0)

Guidance literature:

4-hydroxy-6-methylnicotinic acid; With trichlorophosphate; for 2h; Reflux;

methanol; at 20 ℃; Cooling with ice;

upstream raw materials:

methyl 4,6-dichloropyridine-3-carboxylate

Trimethylboroxine

methanol

4-chloro-6-methylnicotinic acid

Downstream raw materials:

(4-(4-chloro-2-fluorophenyl)-6-methylpyridin-3-yl) methanol

methyl 4-(4-chloro-2-fluorophenyl)-6-methylnicotinate

6-phenoxymethyl-3,4-dihydro-2H-[2,7]naphthyridin-1-one

2-methyl-6-phenoxymethyl-3,4-dihydro-2H-[2,7]naphthyridin-1-one

Refernces

• 1、 -. "NOVEL PHENYL AND PYRIDYL UREAS ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)". Page/Page column 106; 107. . Retrieved 2020/11/13.
• 2、 -. "NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)". . . Retrieved 2020/11/13.