3-CHLORO-2-IODO-PHENYLAMINE

Base Information

• Chemical Name: 3-CHLORO-2-IODO-PHENYLAMINE
• CAS No.: 70237-25-1
• Molecular Formula: C6H5ClIN
• Molecular Weight: 253.47
• Hs Code.: 2921420090
• Mol file: 70237-25-1.mol

Synonyms:Benzenamine, 3-chloro-2-iodo-;

Chemical Property of 3-CHLORO-2-IODO-PHENYLAMINE

Chemical Property:

• Vapor Pressure: 0.000925mmHg at 25°C
• Refractive Index: 1.694
• Boiling Point: 303.5 °C at 760 mmHg
• PKA: 1.48±0.10(Predicted)
• Flash Point: 137.4 °C
• PSA: 26.02000
• Density: 2.015 g/cm³
• LogP: 3.10800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-2-iodoaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Chloro-2-iodoaniline is used in the preparation of indolyl benzoic acid derivatives as NURR-1 activators for the treatment of Parkinson's disease. 3-Chloro-2-iodoaniline is used in the preparation of indolyl benzoic acid derivatives as NURR-1 activators for the treatment of Parkinson''s disease.

Technology Process of 3-CHLORO-2-IODO-PHENYLAMINE

There total 12 articles about 3-CHLORO-2-IODO-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-chloro-2-iodo-3-nitrobenzene (32337-97-6) → 3-chloro-2-iodobenzenamine (70237-25-1)

Guidance literature:

With stannous chloride dihydrate; In ethanol; at 70 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo9012755

Reference yield: 55.0%

2-chloro-6-nitrophenol (603-86-1) → 3-chloro-2-iodobenzenamine (70237-25-1)

Guidance literature:

Reference yield:

N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide (1244651-34-0) → 3-chloro-2-iodobenzenamine (70237-25-1) + 3-chloro-aniline (108-42-9)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 90 ℃; for 6h;

DOI:10.1021/jo200406f

upstream raw materials:

2-chloro-6-nitrophenol

1-chloro-2-iodo-3-nitrobenzene

3-chloro-2-iodophenyl N,N-dimethyl O-carbamate

N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide

Downstream raw materials:

5-chloro-3,4-dihydro-2(1H)-quinolinone

2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile

2-mercapto-7-chlorobenzothiazole

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