5-Bromo-2-methoxythiazole

Base Information

• Chemical Name: 5-Bromo-2-methoxythiazole
• CAS No.: 446287-05-4
• Molecular Formula: C4H4BrNOS
• Molecular Weight: 194.05000
• Hs Code.: 2934100090
• European Community (EC) Number: 692-027-5
• DSSTox Substance ID: DTXSID90586040
• Wikidata: Q82478070
• Mol file: 446287-05-4.mol

Synonyms:5-Bromo-2-methoxythiazole;446287-05-4;5-Bromo-2-methoxy-1,3-thiazole;MFCD09025733;Thiazole, 5-bromo-2-methoxy-;SCHEMBL2430393;DTXSID90586040;BGUMXMYDARUQAH-UHFFFAOYSA-N;WSA28705;AKOS006343974;5-bromo-2-methoxythiazole, AldrichCPR;CS-W001573;MB06715;PS-3838;SY065469;DB-070580;EN300-206791;J-516964

Chemical Property of 5-Bromo-2-methoxythiazole

Chemical Property:

• Vapor Pressure: 0.168mmHg at 25°C
• Boiling Point: 220.4oC at 760 mmHg
• PKA: 1.52±0.10(Predicted)
• Flash Point: 87.1oC
• PSA: 50.36000
• Density: 1.727g/cm3
• LogP: 1.91420
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 192.91970
• Heavy Atom Count: 8
• Complexity: 82.4

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-methoxythiazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=C(S1)Br

Technology Process of 5-Bromo-2-methoxythiazole

There total 3 articles about 5-Bromo-2-methoxythiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxythiazole (14542-13-3) → 5-bromo-2-methoxythiazole (446287-05-4)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 15 ℃; for 16h;

Reference yield:

2,5-dibromo-1,3-thiazole (4175-78-4) + sodium methylate (124-41-4) → 5-bromo-2-methoxythiazole (446287-05-4)

Guidance literature:

In methanol; at 30 ℃; for 12h;

Reference yield:

→ 5-bromo-2-methoxythiazole (446287-05-4)

Guidance literature:

upstream raw materials:

2,5-dibromo-1,3-thiazole

sodium methylate

2-methoxythiazole

Downstream raw materials:

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole

(2-methoxy-1,3-thiazol-5-yl)boronic acid

Refernces

• 1、 -. "Dihydroisoquinoline compound". Paragraph 0479-0484. . Retrieved 2020/07/24.