Fmoc-Lys(For)-OH

Base Information

• Chemical Name: Fmoc-Lys(For)-OH
• CAS No.: 201004-23-1
• Molecular Formula: C22H24N2O5
• Molecular Weight: 396.443
• Mol file: 201004-23-1.mol

Synonyms:(2S)-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoic acid;FMOC-LYSINE(FOR)-OH;Fmoc-Lys(For);2-(N-fluorenylmethyloxycarbonyl)-6-N-formyl-L-lysine;FMOC-LYS(CHO)-OH;Fmoc-formyl lysine;

Chemical Property of Fmoc-Lys(For)-OH

Chemical Property:

• Boiling Point: 705.1±60.0 °C(Predicted)
• PKA: 3.87±0.21(Predicted)
• PSA: 104.73000
• Density: 1.258±0.06 g/cm3(Predicted)
• LogP: 4.31230
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

N-alpha-Fmoc-Nε-formyl-L-lysine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fmoc-Lys(For)-OH

There total 1 articles about Fmoc-Lys(For)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

formic acid (64-18-6) + Fmoc-Lys-OH (105047-45-8) → (2S)-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoic acid (201004-23-1)

Guidance literature:

In tetrahydrofuran; acetic anhydride; at 20 ℃;

DOI:10.1021/ja0648460

Reference yield: 60.0%

benzyl bromide (100-39-0) + (2S)-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoic acid (201004-23-1) → (2S)-benzyl 2-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoate (1378235-07-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1021/np200972s

Reference yield:

Fmoc-Gly-OPfp (86060-85-7) + N-α-Fmoc-L-phenylalanine pentafluorophenyl ester (86060-92-6,159505-85-8) + (2S)-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoic acid (201004-23-1) + Fmoc-Thr(tBu) pentafluorophenyl ester → FGK(For)FTGARKSARK-NH2

Guidance literature:

Multistep reaction;

DOI:10.1016/S0223-5234(03)00087-4

upstream raw materials:

formic acid

Fmoc-Lys-OH

Downstream raw materials:

(2S)-benzyl 6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoate

(2S)-benzyl 6-formamido-2-[(4R)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoate

(2S)-6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid

(2S)-6-formamido-2-[(4R)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid

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