7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine

Base Information

• Chemical Name: 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine
• CAS No.: 772318-01-1
• Molecular Formula: C₂₄H₂₈N₄O₃S
• Molecular Weight: 452.577
• Mol file: 772318-01-1.mol

Synonyms:

Chemical Property of 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine

There total 15 articles about 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine (772318-01-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: pyridine

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

7.1: TFA / CH₂Cl₂

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine (772318-01-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: pyridine

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

7.1: TFA / CH₂Cl₂

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → 7-({methanesulfonyl-[4-(piperidin-4-yloxy)-phenyl]-amino}-methyl)-naphthalene-2-carboxamidine (772318-01-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

2.1: pyridine

3.1: Cs₂CO₃ / dimethylformamide

4.1: NH₂OH / ethanol

5.1: acetic anhydride; acetic acid

5.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

6.1: TFA / CH₂Cl₂

With pyridine; hydrogen; hydroxylamine; acetic anhydride; caesium carbonate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00927-7

upstream raw materials:

4-{4-[(7-carbamimidoyl-naphthalen-2-ylmethyl)-methanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

7-methyl-2-naphthalene carbonitrile

7-methoxy-2-naphthol

7-hydroxynaphthalene-2-carbonitrile