tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Base Information

Chemical Name:tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
CAS No.:198835-03-9
Molecular Formula:C₁₁H₁₉NO₃
Molecular Weight:213.277
Hs Code.:
Mol file:198835-03-9.mol

Synonyms:tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;1932042-59-5;198835-03-9;rel-tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;SCHEMBL20633608;AMY35409;YHA83503;MFCD17016678;MFCD30228539;AKOS037644528;AS-53904;CS-0059091;D72187;EN300-315884;P17268;2-Boc-(1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane;rel-(1S,4S,5R)-2-Boc-5-hydroxy-2-azabicyclo[2.2.1]heptane;t-Butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;tert-butyl(1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;rac-tert-butyl (1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate;Rel-t-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Suppliers and Price of tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
rel-tert-Butyl(1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
1g
$ 507.00

ChemScene
rel-tert-Butyl(1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
5g
$ 1742.00

Chemenu
rel-tert-butyl(1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 95%+
25g
$ 3880.00

Chemenu
rel-tert-butyl(1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 95%+
10g
$ 1940.00

Chemenu
rel-tert-butyl(1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 95%+
5g
$ 1164.00

Chemenu
rel-tert-butyl(1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate 95%+
1g
$ 339.00

AK Scientific
Racemic-(1R,4R,5S)-Tert-Butyl5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate
100mg
$ 201.20

Total 8 raw suppliers

Chemical Property of tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Chemical Property:

Boiling Point:310.3±35.0 °C(Predicted)
PKA:14.70±0.20(Predicted)
Density:1.181±0.06 g/cm3(Predicted)
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:213.13649347
Heavy Atom Count:15
Complexity:272

Purity/Quality:

97% ^*data from raw suppliers

rel-tert-Butyl(1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC2CC1CC2O
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1C[C@H]2O

Technology Process of tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

There total 30 articles about tert-butyl (1S,4S,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 198835-06-2
5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 198835-03-9,198835-07-3,1932042-59-5
tert-butyl (1RS,4RS,5RS)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.666667h;
DOI:10.1016/j.tet.2011.11.035

Reference yield: 97.4%

: 1400808-00-5,198835-06-2
5-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 198835-03-9,198835-07-3,1932042-59-5
(1R,4R,5R)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; Cooling with ice;

Reference yield: 61.0%

: 702666-73-7
tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate

: 207405-69-4,198835-03-9,198835-07-3,1932042-59-5
(1R,4R,5S)-tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptanes-2-carboxylate

Guidance literature:: tert-butyl (1R,4S)-(+)-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; at 23 ℃; for 0.5h; Inert atmosphere;

With dimethyl sulfate; In tetrahydrofuran; at 35 ℃; for 4h;

With water; dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 23 ℃; for 1h;