4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

Base Information

Chemical Name:4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin
CAS No.:1292297-06-3
Molecular Formula:C₁₈H₁₆O₆
Molecular Weight:328.321
Hs Code.:

Synonyms:

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Chemical Property of 4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

Chemical Property:

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Technology Process of 4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

There total 4 articles about 4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 622864-48-6
(3-hydroxy-4-methoxyphenyl)boronic acid

: 1214736-47-6
5,6-dimethoxy-4-trifluoromethylsulfonyloxychromen-2-one

: 1292297-06-3
4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; benzene; Reflux;
DOI:10.1021/jm901826e

Reference yield:

: 78504-28-6
2-Benzyloxy-4-bromo-1-methoxybenzene

: 1292297-06-3
4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; benzene / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jm901826e

Reference yield:

: 103989-79-3
4-hydroxy-5,6-dimethoxy-coumarin

: 1292297-06-3
4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; benzene / Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm901826e