Boronic acid, (3-hydroxy-4-methoxyphenyl)- (9CI)

Base Information

• Chemical Name: Boronic acid, (3-hydroxy-4-methoxyphenyl)- (9CI)
• CAS No.: 622864-48-6
• Molecular Formula: C7H9BO4
• Molecular Weight: 167.957
• Hs Code.: 2931900090
• Mol file: 622864-48-6.mol

Synonyms:Boronic acid, (3-hydroxy-4-methoxyphenyl)- (9CI);3-Hydroxy-4-methoxybenzeneboronic acid

Chemical Property of Boronic acid, (3-hydroxy-4-methoxyphenyl)- (9CI)

Chemical Property:

• Melting Point: 221 °C
• Boiling Point: 380.5±52.0 °C(Predicted)
• PKA: 8.63±0.10(Predicted)
• PSA: 69.92000
• Density: 1.32±0.1 g/cm3(Predicted)
• LogP: -0.91940
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-4-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boronic acid, (3-hydroxy-4-methoxyphenyl)- (9CI)

There total 2 articles about Boronic acid, (3-hydroxy-4-methoxyphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3-(benzyloxy)-4-methoxyphenyl)boronic acid (243990-54-7) → (3-hydroxy-4-methoxyphenyl)boronic acid (622864-48-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; for 24h;

DOI:10.1021/jm901826e

Reference yield:

2-Benzyloxy-4-bromo-1-methoxybenzene (78504-28-6) → (3-hydroxy-4-methoxyphenyl)boronic acid (622864-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h

With n-butyllithium; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran;

DOI:10.1021/jm901826e

Reference yield: 97.0%

trifluoromethanesulfonic acid 6-methoxy-2-oxo-2H-chromen-4-yl ester (638191-28-3) + (3-hydroxy-4-methoxyphenyl)boronic acid (622864-48-6) → 4-(3-hydroxy-4-methoxyphenyl)-6-methoxy-2H-chromen-2-one (1292297-05-2)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; benzene; Reflux;

DOI:10.1021/jm901826e

upstream raw materials:

2-Benzyloxy-4-bromo-1-methoxybenzene

(3-(benzyloxy)-4-methoxyphenyl)boronic acid

Downstream raw materials:

3'-hydroxy-4',5,7-trimethoxy-4-phenyl-2H-1-benzopyran-2-one

4-(3-hydroxy-4-methoxyphenyl)-6-methoxy-2H-chromen-2-one

4-(3'-hydroxy-4'-methoxyphenyl)-5,6-dimethoxycoumarin

4-(3-hydroxy-4-methoxyphenyl)-2H-chromen-2-one