2-aMino-3-(trifluoroMethyl)phenol

Base Information

• Chemical Name: 2-aMino-3-(trifluoroMethyl)phenol
• CAS No.: 106877-48-9
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.12
• Hs Code.: 2922299090
• Mol file: 106877-48-9.mol

Synonyms:2-Amino-3-(trifluoromethyl)phenol;

Chemical Property of 2-aMino-3-(trifluoroMethyl)phenol

Chemical Property:

• Boiling Point: 229.1 °C at 760 mmHg
• PKA: 8.75±0.10(Predicted)
• Flash Point: 92.3 °C
• PSA: 46.25000
• Density: 1.432 g/cm³
• LogP: 2.57440
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-trifluoromethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-3-trifluoromethylphenol, is an intermediate in the synthesis of pharmaceutical compounds including inhibitors. It can also be used for the preparation of pesticides with a trufluoromethyl moiety.

Technology Process of 2-aMino-3-(trifluoroMethyl)phenol

There total 3 articles about 2-aMino-3-(trifluoroMethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-nitro-3-(trifluoromethyl)phenol (386-72-1) → 2-amino-3-(trifluoromethyl)phenol (106877-48-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol;

Reference yield: 19.0%

Bromotrifluoromethane (75-63-8) + 2-amino-phenol (95-55-6) → 2-hydroxy-4-(trifluoromethyl)aniline (454-82-0) + 2-amino-3-(trifluoromethyl)phenol (106877-48-9)

Guidance literature:

With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 2h; under 2250.2 - 3750.3 Torr;

Reference yield:

2,6-difluoro-N-(2-hydroxy-6-(trifluoromethyl)phenyl)benzamide (1431458-25-1) → 2-amino-3-(trifluoromethyl)phenol (106877-48-9)

Guidance literature:

With hydrazine hydrate; at 100 ℃; for 4h; Sealed tube;

DOI:10.1021/ol400437a

upstream raw materials:

Bromotrifluoromethane

2-amino-phenol

2-nitro-3-(trifluoromethyl)phenol

2,6-difluoro-N-(2-hydroxy-6-(trifluoromethyl)phenyl)benzamide

Refernces

• 1、 -. "PIPERIDINONES USEFUL IN THE TREATMENT OF INFLAMMATION". Page/Page column 106. . Retrieved 2008/12/07.