Technology Process of (3S,6R)-2-Methoxy-2-oxo-3-(2-phenoxy-acetylamino)-2λ5-[1,2]oxaphosphinane-6-carboxylic acid tert-butyl ester
There total 20 articles about (3S,6R)-2-Methoxy-2-oxo-3-(2-phenoxy-acetylamino)-2λ5-[1,2]oxaphosphinane-6-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 35 percent / glacial acetic acid / 1.) 22 deg C, 1 h; 2.) 85 deg C, 1.5 h
2: N-methylmorpholine oxide dihydrate, osmium tetroxide / tetrahydrofuran; H2O / 22 °C
3: 81 percent / 2N NaOH / H2O / 25 °C
4: dicyclohexylcarbodiimide, pyridine / CH2Cl2
5: methanol
6: 89 percent / O2 / 10percent Pt/C / H2O / 36 h / 50 °C
7: oxalyl chloride, dimethylformamide / CH2Cl2 / 1.) 30 min., 0 deg C; 2.) 45 min., r.t.
8: triethylamine / CH2Cl2 / 12 h / 21 °C
9: H2 / 10percent Pt/C / ethyl acetate / 3 h / 760 Torr
10: triethylamine / CH2Cl2 / 12 h / 21 °C
With
pyridine; sodium hydroxide; osmium(VIII) oxide; oxalyl dichloride; hydrogen; oxygen; acetic acid; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 35 percent / glacial acetic acid / 1.) 22 deg C, 1 h; 2.) 85 deg C, 1.5 h
2: N-methylmorpholine oxide dihydrate, osmium tetroxide / tetrahydrofuran; H2O / 22 °C
3: 81 percent / 2N NaOH / H2O / 25 °C
4: dicyclohexylcarbodiimide, pyridine / CH2Cl2
5: methanol
6: 89 percent / O2 / 10percent Pt/C / H2O / 36 h / 50 °C
7: oxalyl chloride, dimethylformamide / CH2Cl2 / 1.) 30 min., 0 deg C; 2.) 45 min., r.t.
8: triethylamine / CH2Cl2 / 12 h / 21 °C
9: H2 / 10percent Pt/C / ethyl acetate / 3 h / 760 Torr
10: triethylamine / CH2Cl2 / 12 h / 21 °C
With
pyridine; sodium hydroxide; osmium(VIII) oxide; oxalyl dichloride; hydrogen; oxygen; acetic acid; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: methanol
2: 89 percent / O2 / 10percent Pt/C / H2O / 36 h / 50 °C
3: oxalyl chloride, dimethylformamide / CH2Cl2 / 1.) 30 min., 0 deg C; 2.) 45 min., r.t.
4: triethylamine / CH2Cl2 / 12 h / 21 °C
5: H2 / 10percent Pt/C / ethyl acetate / 3 h / 760 Torr
6: triethylamine / CH2Cl2 / 12 h / 21 °C
With
oxalyl dichloride; hydrogen; oxygen; triethylamine; N,N-dimethyl-formamide;
platinum on activated charcoal;
In
methanol; dichloromethane; water; ethyl acetate;
