(E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID

Base Information

Chemical Name:(E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID
CAS No.:917942-73-5
Molecular Formula:C14 H9 Br Cl N O2
Molecular Weight:338.58
Hs Code.:
Mol file:917942-73-5.mol

Synonyms:(E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID

Suppliers and Price of (E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID

Chemical Property:

Vapor Pressure:5.91E-10mmHg at 25°C
Boiling Point:478.2°C at 760 mmHg
PKA:2.84±0.36(Predicted)
Flash Point:243°C
PSA：50.19000
Density:1.639g/cm³
LogP:4.36610

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID

There total 1 articles about (E)-2-(4-BROMOSTYRYL)-5-CHLORONICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1122-91-4
4-bromo-benzaldehyde

: 350597-49-8
2-methyl-5-chloro methylnicotinate

: 917942-73-5
C₁₄H₉BrClNO₂

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm200112k

Reference yield: 35.0%

: 917942-73-5
C₁₄H₉BrClNO₂

: 917878-65-0
7-bromo-3-chloro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one

Guidance literature:: With polyphosphoric acid; at 200 ℃; Inert atmosphere;
DOI:10.1021/jm200112k

Reference yield:

: 917942-73-5
C₁₄H₉BrClNO₂

: N-[3-(2-chlorophenyl)-5-oxo-5H-benzo[4,5]cyclohepta-[1,2-b]pyridin-7-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: polyphosphoric acid / 200 °C / Inert atmosphere

2.1: Benzophenone imine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 2.5 h / 110 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: triethylamine / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere

With Benzophenone imine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium t-butanolate; In 1,4-dioxane; toluene;
DOI:10.1021/jm200112k