tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate
• CAS No.: 308386-38-1
• Molecular Formula: C16H22BrNO3
• Molecular Weight: 356.26
• Hs Code.: 2933399090
• Mol file: 308386-38-1.mol

Synonyms:1-BOC-4-(4-bromophenoxy)piperidine;tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate;1-N-Boc-4-(4-bromophenoxy)piperidine

Chemical Property of tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 418.6±35.0 °C(Predicted)
• PKA: -2.47±0.40(Predicted)
• PSA: 38.77000
• Density: 1.317±0.06 g/cm3(Predicted)
• LogP: 4.16530
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-BOC-4-(4-bromophenoxy)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate

There total 3 articles about tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.3%

4-bromo-phenol (106-41-2) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(4-bromophenoxy) piperidine-1-carboxylate (308386-38-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ardp.201800267

Reference yield: 64.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + 1-Bromo-4-fluorobenzene (460-00-4) → tert-butyl 4-(4-bromophenoxy) piperidine-1-carboxylate (308386-38-1)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 2.5h;

1-Bromo-4-fluorobenzene; In N,N-dimethyl-formamide; at 120 ℃; for 12h;

Reference yield: 36.0%

→ tert-butyl 4-(4-bromophenoxy) piperidine-1-carboxylate (308386-38-1)

Guidance literature:

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

1-Bromo-4-fluorobenzene

4-bromo-phenol

Downstream raw materials:

C₂₃H₂₂N₂OS

C₂₇H₂₉N₃O₃S

phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate

4-(4-cyclopropylphenoxy)piperidine