phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate

Base Information

• Chemical Name: phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate
• CAS No.: 778642-37-8
• Molecular Formula: C₂₉H₃₈N₂O₆
• Molecular Weight: 510.631
• Mol file: 778642-37-8.mol

Synonyms:phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate

Chemical Property of phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate

There total 3 articles about phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate (778642-37-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

benzyl 4-oxo-1-piperidinecarboxylate; In tetrahydrofuran; hexane; at -70 ℃; for 18h;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + tert-butyl 4-(4-bromophenoxy) piperidine-1-carboxylate (308386-38-1) → phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate (778642-37-8)

Guidance literature:

tert-butyl 4-(4-bromophenoxy) piperidine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; hexane; at -75 - -70 ℃; for 0.333333h;

benzyl 4-oxo-1-piperidinecarboxylate; In tetrahydrofuran; hexane; at -70 - 20 ℃;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → phenylmethyl 4-{4-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)oxy]phenyl}-4-hydroxy-1-piperidinecarboxylate (778642-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / dichloromethane / 65 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -75 - -70 °C

2.2: -70 - 20 °C

With n-butyllithium; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

tert-butyl 4-(4-bromophenoxy) piperidine-1-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

1-(1-methylethyl)-4-{[4-(4-piperidinyl)phenyl]oxy}piperidine

1-{[4-(1-azetidinylcarbonyl)phenyl]carbonyl}-4-(4-{[1-(1-methylethyl)-4-piperidinyl]oxy}phenyl)piperidine

phenylmethyl 4-[4-(4-piperidinyloxy)phenyl]-1-piperidinecarboxylate

4-[4-(4-piperidinyloxy)phenyl]-3,6-dihydro-1(2H)-pyridinecarboxylate