DBCO-PEG4-biotin

Base Information

Chemical Name:DBCO-PEG4-biotin
CAS No.:1255942-07-4
Molecular Formula:C₃₉H₅₁N₅O₈S
Molecular Weight:749.929
Hs Code.:
Mol file:1255942-07-4.mol

Synonyms:

Suppliers and Price of DBCO-PEG4-biotin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DBCO-PEG4-Biotin
1mg
$ 65.00

Sigma-Aldrich
Dibenzocyclooctyne-PEG4-biotin conjugate for Copper-free Click Chemistry
5mg
$ 93.70

purepeg
DBCO-NH-PEG4-Biotin min.95%
100 mg
$ 650.00

Iris Biotech GmbH
Biotin-PEG(4)-DBCO
250 mg
$ 2160.00

Iris Biotech GmbH
Biotin-PEG(4)-DBCO
100 mg
$ 1080.00

Chem-Impex
Biotin-PEG4-DBCO,95%(HPLC) 95%(HPLC)
25MG
$ 302.40

Chem-Impex
Biotin-PEG4-DBCO,95%(HPLC) 95%(HPLC)
5MG
$ 151.20

Chem-Impex
Biotin-PEG4-DBCO,≥95%(HPLC) ≥95%(HPLC)
100MG
$ 1158.98

BroadPharm
DBCO-PEG4-biotin 95%
100 MG
$ 1295.00

Total 7 raw suppliers

Chemical Property of DBCO-PEG4-biotin

Chemical Property:

Boiling Point:1062.4±65.0 °C(Predicted)
PKA:13.90±0.40(Predicted)
Density:1.30±0.1 g/cm3(Predicted)
Storage Temp.:?20°C
Solubility.:Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

98%,99%, ^*data from raw suppliers

DBCO-PEG4-Biotin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description DBCO-PEG4-biotin is a click chemistry biotinylation that can enable copper-free click chemistry with azide molecules to form a stable triazole linkage. PEG4 spacer increases aqueou solubility of the molecules conjugated to the biotin compound.
Uses activity-based protein profiling detection of newly synthesized proteins immobilization of azide-labeled biomolecules. DBCO-PEG4-Biotin is used in preparation of array-based cyclic peptide libraries.

Technology Process of DBCO-PEG4-biotin

There total 8 articles about DBCO-PEG4-biotin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1255942-06-3
N-(3-aminopropionyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocine

: 721431-18-1
1 7-oxo-21-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3 ,4-d]imidazol-4-yl)-4,7,10,13-tetraoxa-16-azahenicosan-1-oic acid

: 1255942-07-4
DBCO-4PEG-biotin

Guidance literature:: 1 7-oxo-21-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3 ,4-d]imidazol-4-yl)-4,7,10,13-tetraoxa-16-azahenicosan-1-oic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

N-(3-aminopropionyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/bc100306u

Reference yield:

: C₂₀H₁₇F₃N₂O₂

: 1255942-07-4
DBCO-4PEG-biotin

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium perbromide hydrobromide / dichloromethane / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

3.1: potassium carbonate / methanol; water / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

4.2: 3 h / 20 °C

With pyridinium perbromide hydrobromide; potassium tert-butylate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/bc100306u

Reference yield:

: C₂₀H₁₇Br₂F₃N₂O₂

: 1255942-07-4
DBCO-4PEG-biotin

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate / methanol; water / 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

3.2: 3 h / 20 °C

With potassium tert-butylate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/bc100306u