3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline

Base Information

• Chemical Name: 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline
• CAS No.: 83520-09-6
• Molecular Formula: C₂₇H₂₅Cl₂N₅O₅
• Molecular Weight: 570.432
• Mol file: 83520-09-6.mol

Synonyms:

Chemical Property of 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline

There total 9 articles about 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline (83520-09-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) AcOH / 1.) EtOH, Rt, 22 h, 2.) benzene, reflux, 3 h

2: 77 percent / NH₂NH₂*H₂O, AcOH / ethanol / 2 h / Heating

3: 81.7 percent / dimethylformamide / Ambient temperature

4: 89.6 percent / 30percent HBr-AcOH / 1.5 h / Ambient temperature

5: hexamethylphosphoric acid triamide; acetonitrile / Ambient temperature

With hydrogen bromide; hydrazine hydrate; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00354a015

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) → 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline (83520-09-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hexamethylphosphoric acid triamide / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: 3.75 g / HCl gas / diethyl ether / 0 °C

3: 2.) AcOH / 1.) EtOH, RT, 8 d, 2.) benzene, reflux, 1.5 h

4: AcOH / ethanol / Ambient temperature

With hydrogenchloride; acetic acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol;

DOI:10.1021/jm00354a015

Reference yield:

<<(benzyloxycarbonyl)glycyl>amino>acetonitrile (20855-76-9) → 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline (83520-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 3.75 g / HCl gas / diethyl ether / 0 °C

2: 2.) AcOH / 1.) EtOH, RT, 8 d, 2.) benzene, reflux, 1.5 h

3: AcOH / ethanol / Ambient temperature

With hydrogenchloride; acetic acid; In diethyl ether; ethanol;

DOI:10.1021/jm00354a015

upstream raw materials:

N-(benzyloxycarbonyl)glycyl chloride

N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide

acetic acid hydrazide

2-(2-Benzyloxycarbonylamino-acetylamino)-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester

Downstream raw materials:

2',5-dichloro-2-(3-glycylaminomethyl-5-methyl-4H-1,2,4-triazol-4-yl)-benzophenone

2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone