Despropionyl p-Fluoro Fentanyl

Base Information

• Chemical Name: Despropionyl p-Fluoro Fentanyl
• CAS No.: 122861-41-0
• Molecular Formula: C₁₉H₂₃FN₂
• Molecular Weight: 298.403
• Mol file: 122861-41-0.mol

Synonyms:N-(4-Fluorophenyl)-1-(2-phenylethyl)piperidin-4-amine;Despropionyl p-fluoro fentanyl;

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Chemical Property of Despropionyl p-Fluoro Fentanyl

Chemical Property:

• Boiling Point: 424.346 °C at 760 mmHg
• Flash Point: 210.437 °C
• PSA: 15.27000
• Density: 1.126 g/cm³
• LogP: 3.95560
• Storage Temp.: Refrigerator

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Despropionyl para-Fluorofentanyl (CRM) (Item No. 26428) is a certified reference material that is structurally similar to known opioids. It is a metabolite of FIBF (Item Nos. 19795 | 19313), and a precursor in the synthesis of para-fluorofentanyl, and a potential impurity in para-fluorofentanyl preparations. This product is intended for research and forensic applications.
• Uses: An intermediate in the production of fentanyl analogs.

Technology Process of Despropionyl p-Fluoro Fentanyl

There total 4 articles about Despropionyl p-Fluoro Fentanyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → N-[1-(2-phenylethyl)-4-piperidyl]-N-(4-fluorophenyl)amine (122861-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluene sulfonic acid / toluene / 5 h / Heating; Dean-Stark trap

2: sodium borohydride / methanol / 2 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; toluene;

Reference yield:

4-fluoroaniline (371-40-4) → N-[1-(2-phenylethyl)-4-piperidyl]-N-(4-fluorophenyl)amine (122861-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluene sulfonic acid / toluene / 5 h / Heating; Dean-Stark trap

2: sodium borohydride / methanol / 2 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; toluene;

Reference yield:

(4-fluoro-phenyl)-(1-phenethyl-piperidin-4-ylidene)-amine → N-[1-(2-phenylethyl)-4-piperidyl]-N-(4-fluorophenyl)amine (122861-41-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h; Heating;

upstream raw materials:

1-(2-phenylethyl)-4-piperidinone

4-fluoroaniline

Downstream raw materials:

4-fluoroisobutyrylfentanyl