5F-MN18

Base Information

• Chemical Name: 5F-MN18
• CAS No.: 244195-32-2
• Molecular Formula: C₂₃H₂₉FN₂O
• Molecular Weight: 368.494

Synonyms:

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Chemical Property of 5F-MN18

Chemical Property:

• Boiling Point: 486.4±45.0 °C(Predicted)
• PKA: 8.91±0.20(Predicted)
• Density: 1.114±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5F-MN18

There total 4 articles about 5F-MN18 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → 4-fluoroisobutyrylfentanyl (244195-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Molecular sieve

2: sodium tetrahydroborate

3: sodium tetrahydroborate

With sodium tetrahydroborate;

DOI:10.1248/bpb.b20-00780

Reference yield:

4-fluoroaniline (371-40-4) → 4-fluoroisobutyrylfentanyl (244195-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Molecular sieve

2: sodium tetrahydroborate

3: sodium tetrahydroborate

With sodium tetrahydroborate;

DOI:10.1248/bpb.b20-00780

Reference yield:

(4-fluoro-phenyl)-(1-phenethyl-piperidin-4-ylidene)-amine → 4-fluoroisobutyrylfentanyl (244195-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate

2: sodium tetrahydroborate

With sodium tetrahydroborate;

DOI:10.1248/bpb.b20-00780

upstream raw materials:

1-(2-phenylethyl)-4-piperidinone

4-fluoroaniline

N-[1-(2-phenylethyl)-4-piperidyl]-N-(4-fluorophenyl)amine

isobutyryl chloride