(R)-(+)-1-Amino-1-phenylpropaneHCl

Base Information

• Chemical Name: (R)-(+)-1-Amino-1-phenylpropaneHCl
• CAS No.: 19068-33-8
• Molecular Formula: C9H14ClN
• Molecular Weight: 171.67
• Hs Code.: 2921499090
• Mol file: 19068-33-8.mol

Synonyms:(R)-alpha-Ethylbenzenemethanamine hydrochloride

Chemical Property of (R)-(+)-1-Amino-1-phenylpropaneHCl

Chemical Property:

• Vapor Pressure: 0.272mmHg at 25°C
• Boiling Point: 203.9 °C at 760 mmHg
• Flash Point: 85.1 °C
• PSA: 26.02000
• LogP: 3.59870

Purity/Quality:

99% ^*data from raw suppliers

(1-phenylpropyl)aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(+)-1-Amino-1-phenylpropaneHCl

There total 17 articles about (R)-(+)-1-Amino-1-phenylpropaneHCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(1-phenylpropyl)-diphenylphosphinamide (106651-16-5) → (R)-1-phenylpropan-1-amine hydrochloride (19068-33-8)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1002/adsc.200606128

Reference yield: 88.6%

bromobenzene (108-86-1,52753-63-6) + Ss-2-methyl-propane-2-sulfinic acid propylideneamide → (R)-1-phenylpropan-1-amine hydrochloride (19068-33-8)

Guidance literature:

bromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -50 - -40 ℃;

S_s-2-methyl-propane-2-sulfinic acid propylideneamide; In tetrahydrofuran; hexane; at -50 - -40 ℃;

With hydrogenchloride; In isopropyl alcohol; for 1h; enantioselective reaction;

DOI:10.1080/00397911.2014.909487

Reference yield: 81.0%

(RS)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide (196929-90-5) → (R)-1-phenylpropan-1-amine hydrochloride (19068-33-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jo0609834

upstream raw materials:

ethyl bromide

benzhydrylidene-benzyl-amine

(R_S)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide

ethylmagnesium bromide

Downstream raw materials:

(R)-N-(1-phenylpropyl)acetamide

(R_S)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide

Refernces

• 1、 Rajendiran, Chinnapillai,Nagarajan, Periyandi,Naidu,Dubey. "Reversal diastereoselectivity between the organomagnesium and organolithium reagents on Chiral N-tert-butylsulfinylaldimines for the preparation of chiral amines". . p. 2936 - 2942. Retrieved 2014/11/08.
• 2、 Roe, Caroline,Hobbs, Heather,Stockman, Robert A.. "One-pot synthesis of chiral nonracemic amines". experimental part. p. 9452 - 9459. Retrieved 2012/01/06.