5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

Chemical Name:5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:1296194-45-0
Molecular Formula:C₁₈H₂₀N₂O
Molecular Weight:280.37
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Chemical Property:

Purity/Quality:

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Technology Process of 5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 9 articles about 5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1296194-38-1
1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 98-88-4
benzoyl chloride

: 1296194-45-0,1296888-59-9,1296888-60-2
5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: 1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1002/anie.201007772

Reference yield:

: 1296194-31-4
C₁₀H₁₂N₂O

: 1296194-45-0,1296888-59-9,1296888-60-2
5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C / Inert atmosphere

1.2: 0 - 25 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 90 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 25 °C / Inert atmosphere

3.2: 0 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201007772

Reference yield:

: 1296194-25-6
3-(2-methyl-6-nitrophenylamino)propionic acid

: 1296194-45-0,1296888-59-9,1296888-60-2
5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphoric acid; zinc / 1,4-dioxane / 80 - 110 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C / Inert atmosphere

2.2: 0 - 25 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 90 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 25 °C / Inert atmosphere

4.2: 0 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; phosphoric acid; sodium hydride; zinc; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201007772