3-(2-methyl-6-nitrophenylamino)propionic acid

Base Information

• Chemical Name: 3-(2-methyl-6-nitrophenylamino)propionic acid
• CAS No.: 1296194-25-6
• Molecular Formula: C₁₀H₁₂N₂O₄
• Molecular Weight: 224.216
• Mol file: 1296194-25-6.mol

Synonyms:

Chemical Property of 3-(2-methyl-6-nitrophenylamino)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-methyl-6-nitrophenylamino)propionic acid

There total 1 articles about 3-(2-methyl-6-nitrophenylamino)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Methyl-6-nitroaniline (570-24-1) + acrylic acid (79-10-7) → 3-(2-methyl-6-nitrophenylamino)propionic acid (1296194-25-6)

Guidance literature:

With sulfuric acid; at 25 - 80 ℃; Inert atmosphere;

DOI:10.1002/anie.201007772

Reference yield:

3-(2-methyl-6-nitrophenylamino)propionic acid (1296194-25-6) → 5-benzoyl-1,6-dimethyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one (1296194-42-7,1296888-55-5,1296888-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphoric acid; zinc / 1,4-dioxane / 80 - 110 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C / Inert atmosphere

2.2: 0 - 25 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 25 °C / Inert atmosphere

3.2: 0 - 25 °C / Inert atmosphere

With phosphoric acid; sodium hydride; zinc; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/anie.201007772

Reference yield:

3-(2-methyl-6-nitrophenylamino)propionic acid (1296194-25-6) → 5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (1296194-45-0,1296888-59-9,1296888-60-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: phosphoric acid; zinc / 1,4-dioxane / 80 - 110 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 25 °C / Inert atmosphere

2.2: 0 - 25 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 90 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 25 °C / Inert atmosphere

4.2: 0 - 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; phosphoric acid; sodium hydride; zinc; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/anie.201007772

upstream raw materials:

2-Methyl-6-nitroaniline

acrylic acid

Downstream raw materials:

5-benzoyl-1,6-dimethyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one

5-benzoyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

5-p-chlorobenzoyl-1,6-dimethyl-2H-1,5-benzodiazepin-2-one

N-{4-[(5,9-dimethyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)carbonyl]phenyl}-2-methylbenzamide