Isopropyl 4-methylphenyl sulfide

Base Information

• Chemical Name: Isopropyl 4-methylphenyl sulfide
• CAS No.: 14905-81-8
• Molecular Formula: C10H14 S
• Molecular Weight: 166.287
• Hs Code.: 2930909090
• Mol file: 14905-81-8.mol

Synonyms:Sulfide,isopropyl p-tolyl (6CI,7CI,8CI); 4-(Isopropylthio)-1-methylbenzene; Isopropyl4-methylphenyl sulfide; Isopropyl p-cresyl sulfide; Isopropyl p-tolyl sulfide

Chemical Property of Isopropyl 4-methylphenyl sulfide

Chemical Property:

• Vapor Pressure: 0.085mmHg at 25°C
• Boiling Point: 233.5°C at 760 mmHg
• Flash Point: 93.6°C
• PSA: 25.30000
• Density: 0.97g/cm³
• LogP: 3.49550

Purity/Quality:

Isopropyl4-methylphenylsulfide 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isopropyl 4-methylphenyl sulfide

There total 22 articles about Isopropyl 4-methylphenyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(isopropylsulfinyl)-4-methylbenzene (1517-74-4,37067-60-0,67529-35-5,50337-53-6) → 1-(isopropylthio)-4-methylbenzene (14905-81-8)

Guidance literature:

With phosphorus trichloride; In acetonitrile; at 25 ℃; for 0.5h; Schlenk technique;

DOI:10.1039/c7ob02834b

Reference yield: 88.0%

para-chlorotoluene (106-43-4) + 2-propanethiol (75-33-2) → 1-(isopropylthio)-4-methylbenzene (14905-81-8)

Guidance literature:

With (R)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; potassium tert-butylate; palladium diacetate; In ⁽²⁾H₈-toluene; at 100 ℃; Inert atmosphere;

Reference yield: 87.0%

methyl magnesium iodide (917-64-6) + 4-(Methylthio)-phenyl isopropyl sulphide (70398-91-3) → 1-(isopropylthio)-4-methylbenzene (14905-81-8)

Guidance literature:

bis(triphenylphosphine)nickel(II) chloride; In diethyl ether; benzene; at 50 ℃; for 1h;

DOI:10.1016/S0040-4020(01)91955-6

upstream raw materials:

isopropyl chloride

para-thiocresol

isopropyl bromide

methyl magnesium iodide

Downstream raw materials:

5-Methyl-2-(isopropylthio)benzoic acid

1-(isopropylsulfinyl)-4-methylbenzene

methyl 2-methyl-2-(p-tolylsulfonyl)propanedithioate

<2-(p-tolylsulfonyl)-2-propyl>(methylthio)sulfine

Refernces

• 1、 Li, Jian,Yang, Xin-Er,Wang, Shan-Le,Zhang, Long-Long,Zhou, Xiao-Zhou,Wang, Shun-Yi,Ji, Shun-Jun. "Visible-Light-Promoted Cross-Coupling Reactions of 4-Alkyl-1,4-dihydropyridines with Thiosulfonate or Selenium Sulfonate: A Unified Approach to Sulfides, Selenides, and Sulfoxides". supporting information. p. 4908 - 4913. Retrieved 2020/07/13.
• 2、 Zhao, Xia,Zheng, Xiancai,Yang, Bo,Sheng, Jianqiao,Lu, Kui. "Deoxygenation of sulphoxides to sulphides with trichlorophosphane". . p. 1200 - 1204. Retrieved 2018/02/21.