methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Base Information

• Chemical Name: methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
• CAS No.: 1088994-18-6
• Molecular Formula: C15H21BO4
• Molecular Weight: 276.14
• Hs Code.: 2934999090
• Mol file: 1088994-18-6.mol

Synonyms:methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Chemical Property of methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Chemical Property:

• PSA: 44.76000
• Density: 1.07
• LogP: 2.08080
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

There total 6 articles about methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methoxycarbonyl-3-methylbenzene (99-36-5) + bis(pinacol)diborane (73183-34-3) → 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1088994-18-6)

Guidance literature:

With [Ir(OMe)(COD)]2/tris[3,5-bis(CF₃)phenyl]phosphine; In octane; 80°C, 16 h, benzoate ester (5.0 mmol), bis(pinacolato)diboron (1.0 mmol), (Ir(OMe)(COD))2 (0.015 mmol), tris(3,5-bis(trifluoromethyl)phenyl)phosphine (0.06 mmol);

DOI:10.1039/b910298a

Reference yield: 76.0%

methyl 2-iodo-5-methylbenzoate (103440-52-4) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1088994-18-6)

Guidance literature:

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In 2-methyltetrahydrofuran; at 11 - 60 ℃; for 2.75h; Inert atmosphere;

Reference yield: 76.0%

bis(pinacol)diborane (73183-34-3) + methyl 2-bromo-5-methylbenzoate (90971-88-3) → 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1088994-18-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 85 ℃; for 16h;

DOI:10.1002/chem.201406290

upstream raw materials:

methyl 2-iodo-5-methylbenzoate

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1-methoxycarbonyl-3-methylbenzene

bis(pinacol)diborane

Downstream raw materials:

5-methyl-2-(pyrimidin-2-yl)benzoic acid methyl ester

5-methyl-2-(pyrimidin-2-yl)benzoic acid

MK-6096

2-(5-{5-[5-(2-carboxy-4-methylphenyl)-3-(carboxymethyl)thiophen-2-yl]thiophen-2-yl}-4-(carboxymethyl)thiophen-2-yl)-5-methylbenzoic acid

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