Technology Process of 3,7-dimethyl-1-phenyl-5-((3-(trifluoromethyl)benzylamino)methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one
There total 9 articles about 3,7-dimethyl-1-phenyl-5-((3-(trifluoromethyl)benzylamino)methyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-Trifluoromethylbenzaldehyde; 5-(aminomethyl)-3,7-dimethyl-1-phenyl-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one;
With
acetic acid; triethylamine;
In
methanol;
for 2h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
methanol;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/jm5002937
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: acetic acid / 100 °C
2.1: trichlorophosphate / 70 °C
3.1: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide
4.1: sodium dithionite / methanol
5.1: 150 °C
6.1: lithium tert-butoxide / tetrahydrofuran / 16 h / 0 - 20 °C / Sealed tube
7.1: cobalt(II) chloride hexahydrate / methanol / 2 h / 20 °C
7.2: 16 h / 0 - 20 °C
8.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
9.1: acetic acid; triethylamine / methanol / 2 h / Inert atmosphere
9.2: 16 h / 0 - 20 °C / Inert atmosphere
With
sodium azide; sodium dithionite; cobalt(II) chloride hexahydrate; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; trifluoroacetic acid; lithium tert-butoxide; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm5002937
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trichlorophosphate / 70 °C
2.1: sodium azide; tetra(n-butyl)ammonium hydrogensulfate / dimethyl sulfoxide
3.1: sodium dithionite / methanol
4.1: 150 °C
5.1: lithium tert-butoxide / tetrahydrofuran / 16 h / 0 - 20 °C / Sealed tube
6.1: cobalt(II) chloride hexahydrate / methanol / 2 h / 20 °C
6.2: 16 h / 0 - 20 °C
7.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
8.1: acetic acid; triethylamine / methanol / 2 h / Inert atmosphere
8.2: 16 h / 0 - 20 °C / Inert atmosphere
With
sodium azide; sodium dithionite; cobalt(II) chloride hexahydrate; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; trifluoroacetic acid; lithium tert-butoxide; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm5002937
