2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Base Information

• Chemical Name: 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
• CAS No.: 947191-69-7
• Molecular Formula: C15H22BNO3
• Molecular Weight: 275.156
• Hs Code.: 2934999090
• Mol file: 947191-69-7.mol

Synonyms:2-(Cyclopropylmethoxy)pyridine-5-boronic acid, pinacol ester;2-(Cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;

Chemical Property of 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Chemical Property:

• Vapor Pressure: 1.51E-05mmHg at 25°C
• Boiling Point: 377°C at 760 mmHg
• Flash Point: 181.8°C
• PSA: 40.58000
• Density: 1.09g/cm³
• LogP: 2.16960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

97% ^*data from raw suppliers

2-(Cyclopropylmethoxy)pyridine-5-boronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Cyclopropylmethoxy)pyridine-5-boronic acid, pinacol ester

Technology Process of 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

There total 2 articles about 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-(cyclopropylmethoxy)pyridine (494772-02-0) + bis(pinacol)diborane (73183-34-3) → 2-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (947191-69-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

5-bromo-2-fluoropyridine (766-11-0) → 2-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (947191-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 0 - 20 °C

1.2: 1.5 h / 30 - 130 °C / Microwave irradiation

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield: 99.0%

2-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (947191-69-7) + methyl 4-(((4-bromopyridin-2-yl)oxy)methyl)benzoate → 4-(((6-(cyclopropylmethoxy)-[3,4'-bipyridin]-2'-yl)oxy)methyl)benzoic acid

Guidance literature:

2-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; methyl 4-(((4-bromopyridin-2-yl)oxy)methyl)benzoate; With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydrogencarbonate; In 1,4-dioxane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

With water; sodium hydroxide; In 1,4-dioxane; methanol; at 60 ℃; for 1h;

upstream raw materials:

5-bromo-2-(cyclopropylmethoxy)pyridine

bis(pinacol)diborane

5-bromo-2-fluoropyridine

Downstream raw materials:

6-(2-cyclopropylmethoxy)pyridin-3-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 947191-69-7 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send