2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether

Base Information

• Chemical Name: 2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether
• CAS No.: 25357-24-8
• Molecular Formula: C₁₈H₁₉ClO₇
• Molecular Weight: 382.798
• Mol file: 25357-24-8.mol

Synonyms:

Chemical Property of 2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether

There total 2 articles about 2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (-)-dehydrogriseofulvin (3573-90-8) → 2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether (25357-24-8)

Guidance literature:

With sodium methylate;

DOI:10.1002/hlca.19620450311

Reference yield:

→ 2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether (25357-24-8)

Guidance literature:

(+)-Dehydrogriseofulvin, HCl, Methanol, 4h, Raumtemp.;

DOI:10.1016/0040-4020(63)80001-0

Reference yield:

2-chloro-4′-hydroxy-6-methoxycarbonyl-2′-methyl-3,5,6′-trimethoxydiphenyl ether (25357-24-8) → 2'-Methyl-3,4',5,6'-tetramethoxy-diphenylaether (93728-36-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH

2: H₂SO₄ / acetic acid

3: methanol

4: H₂, KOH / Pd-C / methanol / 50 °C / 38000 Torr

With potassium hydroxide; sodium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; acetic acid;

DOI:10.1002/hlca.19620450311

upstream raw materials:

methanol

(-)-dehydrogriseofulvin

Downstream raw materials:

2-<2,6-Dimethoxy-4-hydroxy-phenoxy>-3-chlor-4,6-dimethoxy-benzoesaeure

2'-Methyl-3,4',5,6'-tetramethoxy-diphenylaether

2-Chlor-4'-hydroxy-2'-methyl-3,5,6'-trimethoxy-diphenylaether

2-Chlor-2'-methyl-3,4',5,6'-tetramethoxy-diphenylaether