Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester

Base Information

• Chemical Name: Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester
• CAS No.: 113795-25-8
• Molecular Formula: C₃₀H₃₇NO₃
• Molecular Weight: 459.629
• Mol file: 113795-25-8.mol

Synonyms:

Chemical Property of Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester

There total 9 articles about Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(p-methoxyphenyl)-4-phenylbutane (38841-95-1) → Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester (113795-25-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine hydrochloride / 4 h / 200 °C

2: NaH / tetrahydrofuran / 8 h / Heating

3: diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 1.) 30 deg C, 30 min, 2.) room temperature, overnight

4: 80.9 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

5: DCC, (dimethylamino)pyridine / CH₂Cl₂ / 2.) room temperature, 2 h, 2.) 0 deg C, 5 h

With dmap; lithium aluminium tetrahydride; n-butyllithium; pyridine hydrochloride; sodium hydride; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm00401a022

Reference yield:

1-(4-methoxyphenyl)-4-phenylbutan-1-one (101594-58-5) → Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester (113795-25-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 80percent hydrazine hydrate, 0.66 mol NaOH / bis-(2-hydroxy-ethyl) ether / 4 h / Heating

2: pyridine hydrochloride / 4 h / 200 °C

3: NaH / tetrahydrofuran / 8 h / Heating

4: diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 1.) 30 deg C, 30 min, 2.) room temperature, overnight

5: 80.9 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

6: DCC, (dimethylamino)pyridine / CH₂Cl₂ / 2.) room temperature, 2 h, 2.) 0 deg C, 5 h

With dmap; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; pyridine hydrochloride; sodium hydride; hydrazine hydrate; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; diethylene glycol;

DOI:10.1021/jm00401a022

Reference yield:

p-(4-phenylbutyl)phenol (36940-99-5) → Nicotinic acid 2,2-dimethyl-6-[4-(4-phenyl-butyl)-phenoxy]-hexyl ester (113795-25-8)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 8 h / Heating

2: diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 1.) 30 deg C, 30 min, 2.) room temperature, overnight

3: 80.9 percent / LiAlH₄ / tetrahydrofuran / 3 h / Ambient temperature

4: DCC, (dimethylamino)pyridine / CH₂Cl₂ / 2.) room temperature, 2 h, 2.) 0 deg C, 5 h

With dmap; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm00401a022

upstream raw materials:

nicotinic acid

2,2-dimethyl-6-<4-(4-phenylbutyl)phenoxy>hexanol

1-(p-methoxyphenyl)-4-phenylbutane

1-(4-methoxyphenyl)-4-phenylbutan-1-one

Refernces