Journal of Medicinal Chemistry p. 1205 - 1209 (1988)
Update date:2022-08-05
Topics:
Morishita, Shin-ichi
Saito, Takashi
Hirai, Yasuharu
Shoji, Masamichi
Mishima, Yasuhiro
Kawakami, Masato
A series of 2-substituted isobutyric acid derivatives have been synthesized and evaluated as hypolipidemic agents.Compounds 11 and 20 were found to decrease the level of plasma total cholesterol in experimental hyperlipidemic rats to a greater extent than clofibrate (CF) and to increase the level of plasma high-density lipoprotein cholesterol to the same extent as gemfibrozil (GF).Increase in liver weight caused by these compounds were less than those with CF and GF.
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Doi:10.1021/jm801648n
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