N-(4-methoxyphenyl)furan-2-carboxamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)furan-2-carboxamide
• CAS No.: 1982-65-6
• Molecular Formula: C12H11 N O3
• Molecular Weight: 217.224
• European Community (EC) Number: 662-503-7
• NSC Number: 191528
• DSSTox Substance ID: DTXSID90941650
• Nikkaji Number: J1.144.560H
• Wikidata: Q82918544
• ChEMBL ID: CHEMBL1213836
• Mol file: 1982-65-6.mol

Synonyms:N-(4-methoxyphenyl)furan-2-carboxamide;1982-65-6;2-Furancarboxamide, N-(4-methoxyphenyl)-;NSC191528;N-(4-Methoxyphenyl)-2-furancarboxamide;CBMicro_009839;Furan-2-carboxylic acid (4-methoxy-phenyl)-amide;Oprea1_644447;SCHEMBL6633618;CHEMBL1213836;N-(4-methoxyphenyl)-2-furamide;4'-METHOXY-2-FURANILIDE;DTXSID90941650;BAPQOHAPCRWHRC-UHFFFAOYSA-N;SMSF0005426;STK083940;AKOS000649815;CB12688;NSC-191528;SB61397;BIM-0009765.P001;EU-0067227;N-(4-Methoxyphenyl)furan-2-carboximidic acid;Z28138935;5266-06-8

Chemical Property of N-(4-methoxyphenyl)furan-2-carboxamide

Chemical Property:

• Vapor Pressure: 0.0106mmHg at 25°C
• Boiling Point: 263°C at 760 mmHg
• Flash Point: 112.9°C
• Density: 1.24g/cm³
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 217.07389321
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC(=O)C2=CC=CO2

Technology Process of N-(4-methoxyphenyl)furan-2-carboxamide

There total 10 articles about N-(4-methoxyphenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxy-aniline (104-94-9) + 2-furanoyl sulfonate (1026046-13-8) → N-(4-methoxyphenyl)-2-furylamide (1982-65-6)

Guidance literature:

With PEG-400; potassium carbonate; In acetonitrile; for 0.25h; Heating;

DOI:10.1080/00397919908086466

Reference yield: 87.0%

furan-2-carboxylic acid phenyl ester (2948-14-3) + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-2-furylamide (1982-65-6)

Guidance literature:

With C₄₀H₅₄ClN₂Pd; caesium carbonate; In tetrahydrofuran; water; at 40 ℃; for 4h; Glovebox; Inert atmosphere;

DOI:10.1021/acs.joc.7b02588

Reference yield: 81.0%

furan-2-carboxylic acid amide (609-38-1) + para-iodoanisole (696-62-8) → N-(4-methoxyphenyl)-2-furylamide (1982-65-6)

Guidance literature:

With potassium carbonate; In neat (no solvent); at 120 ℃; for 16h; Catalytic behavior; Green chemistry;

DOI:10.1039/c6ra24459a

upstream raw materials:

2-furancarbonyl chloride

4-methoxy-aniline

2-furanoyl sulfonate

ethanol

Downstream raw materials:

N-(p-anisyl)furan-2-carboxyimidoyl chloride

furan-2-carbothioic acid p-anisidide