(S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester
CAS No.:81322-85-2
Molecular Formula:C₃₃H₅₄N₄O₈
Molecular Weight:634.814
Hs Code.:

(S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

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Chemical Property of (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

There total 15 articles about (S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 77119-88-1
(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-5-methyl hexanoic acid

: 73604-37-2
Leu-Val-Phe-OCH₃*HCl

: 81322-85-2,81370-21-0
(S)-2-{(S)-2-[(S)-2-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 18h;
DOI:10.1021/jm00347a024

Reference yield: 64.0%

: 73397-27-0
(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-5-methylhexanoic acid

: 73604-37-2
Leu-Val-Phe-OCH₃*HCl

: 81322-85-2,81370-21-0
(S)-2-{(S)-2-[(S)-2-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;
DOI:10.1021/jm00347a024

Reference yield:

: 3183-10-6
N-phthalimide-L-leucinyl chloride

: 81322-85-2,81370-21-0
(S)-2-{(S)-2-[(S)-2-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 5percent Pd/BaSO₄ / xylene / 6 h / 110 °C

2: 100 percent / ZnI₂ / CH₂Cl₂ / 12 h / Ambient temperature

3: 10percent aq. HCl / 1.5 h

4: 6 N aq. HCl / dioxane / 48 h / Heating

5: 100 percent / NEt₃ / H₂O; dioxane / Ambient temperature

7: 64 percent / 1-hydroxybenzotriazole, N-methylmorpholine, dicyclohexylcarbodiimide / tetrahydrofuran; dimethylformamide / 18 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; zinc(II) iodide; Pd-BaSO₄; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm00347a024