(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid

Base Information

Chemical Name:(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid
CAS No.:73397-27-0
Molecular Formula:C12H23 N O5
Molecular Weight:259.34
Hs Code.:2924297099
European Community (EC) Number:688-957-6
DSSTox Substance ID:DTXSID101136700
Nikkaji Number:J1.128.495G
Mol file:73397-27-0.mol

Synonyms:73397-27-0;(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid;Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid;(2S,3S)-2-hydroxy-5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic Acid;n-boc-(2s,3s)-3-amino-2-hydroxy-5-methylhexanoic acid;N-BOC-(2S,3S)-2-HYDROXY-3-AMINO-5-METHYLHEXANOIC ACID;(2S,3S)-3-((tert-butoxycarbonyl)amino)- 2-hydroxy-5-methylhexanoic acid;N-Boc-(2S,3S)-3-amino-2-hydroxy-5-methyl-hexanoic acid;SCHEMBL7320189;DJZCWTDKDFJARG-IUCAKERBSA-N;DTXSID101136700;AMY37469;MFCD04974450;AKOS015949844;PS-12817;CS-0314577;A866097;(2S,3S)-3-(Boc-amino)-2-hydroxy-5-methylhexanoic acid;(2S,3S)-3-(t-butoxycarbonyl)amino-2-hydroxy-5-methylhexaneoic acid;(2S,3S)-2-Hydroxy-3-[(tert-butyloxycarbonyl)amino]-5-methylhexanoic acid;(2S,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-5-methylhexanoic acid;(2S,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-5-methylhexanoic acid;(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-5-methylhexanoic acid

Suppliers and Price of (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
N-Boc-(2S,3S)-2-hydroxy-3-amino-5-methylhexanoicacid
1 g
$ 675.00

Matrix Scientific
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
100mg
$ 179.00

Matrix Scientific
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
500mg
$ 555.00

Matrix Scientific
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
1g
$ 763.00

Crysdot
(2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoicacid 95+%
1g
$ 718.00

Chemenu
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoicacid 95%
1g
$ 678.00

Biosynth Carbosynth
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
500 mg
$ 375.00

Biosynth Carbosynth
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
50 mg
$ 90.00

Biosynth Carbosynth
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
25 mg
$ 50.00

Biosynth Carbosynth
Boc-(2S,3S)-3-amino-2-hydroxy-5-methylhexanoic acid
100 mg
$ 160.00

Total 18 raw suppliers

Chemical Property of (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid

Chemical Property:

PSA：95.86000
LogP:1.76220
Storage Temp.:2-8°C
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:261.15762283
Heavy Atom Count:18
Complexity:295

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-(2S,3S)-2-hydroxy-3-amino-5-methylhexanoicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(C(=O)O)O)NC(=O)OC(C)(C)C
Isomeric SMILES:CC(C)C[C@@H]([C@@H](C(=O)O)O)NC(=O)OC(C)(C)C

Technology Process of (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid

There total 20 articles about (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-5-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 62023-30-7,70853-11-1,70853-17-7,73397-20-3,73397-21-4,75556-30-8
(2RS,3R)-3-Amino-2-hydroxy-5-methylhexanoic Acid

: 73397-25-8,73397-26-9,73397-27-0,73397-28-1,77119-88-1
(2RS,3R)-3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoic Acid

Guidance literature:: With triethylamine; In 1,4-dioxane; water; at 25 ℃;
DOI:10.1021/jo01300a004

Reference yield:

: 3183-10-6
N-phthalimide-L-leucinyl chloride

: 73397-27-0
(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/BaSO₄ / xylene / 6 h / 110 °C

2: 100 percent / ZnI₂ / CH₂Cl₂ / 12 h / Ambient temperature

3: 10percent aq. HCl / 1.5 h

4: 6 N aq. HCl / dioxane / 48 h / Heating

5: 100 percent / NEt₃ / H₂O; dioxane / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; zinc(II) iodide; Pd-BaSO₄; In 1,4-dioxane; dichloromethane; water; xylene;
DOI:10.1021/jm00347a024

Reference yield:

: 2419-38-7
N-phthaloyl-(S)-leucine

: 73397-27-0
(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / benzene / 6 h / Heating

2: H₂ / 5percent Pd/BaSO₄ / xylene / 6 h / 110 °C

3: 100 percent / ZnI₂ / CH₂Cl₂ / 12 h / Ambient temperature

4: 10percent aq. HCl / 1.5 h

5: 6 N aq. HCl / dioxane / 48 h / Heating

6: 100 percent / NEt₃ / H₂O; dioxane / Ambient temperature

With hydrogenchloride; thionyl chloride; hydrogen; triethylamine; zinc(II) iodide; Pd-BaSO₄; In 1,4-dioxane; dichloromethane; water; xylene; benzene;
DOI:10.1021/jm00347a024