3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide

Base Information

• Chemical Name: 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide
• CAS No.: 1253059-02-7
• Molecular Formula: C₁₈H₁₆BrN₃O₃
• Molecular Weight: 402.247
• Mol file: 1253059-02-7.mol

Synonyms:

Chemical Property of 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide

There total 4 articles about 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

3-oxo-N-(p-bromobenzyl)butanamide (1248731-85-2) + 6-methylbenzofuroxan (3524-05-8) → 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide (1253059-02-7) + C18H16BrN3O3

Guidance literature:

With ethanolamine; calcium chloride; In methanol; at 20 ℃;

DOI:10.1016/j.ejmech.2010.06.036

Reference yield:

4-Bromobenzylamine (3959-07-7) → 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide (1253059-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0 °C / Inert atmosphere

2: ethanolamine; calcium chloride / methanol

With ethanolamine; calcium chloride; In methanol; 2: Beirut reaction;

DOI:10.3390/molecules16097893

Reference yield:

4-methyl-2-nitroaniline (89-62-3) → 3,7-dimethylquinoxaline-2-carboxylic acid p-bromobenzylamide 1,4-di-N-oxide (1253059-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hypochlorite / N,N-dimethyl-formamide / 20 °C

2: ethanolamine; calcium chloride / methanol

With sodium hypochlorite; ethanolamine; calcium chloride; In methanol; N,N-dimethyl-formamide; 2: Beirut reaction;

DOI:10.3390/molecules16097893

upstream raw materials:

3-oxo-N-(p-bromobenzyl)butanamide

6-methylbenzofuroxan

4-Bromobenzylamine

4-methyl-2-nitroaniline

Refernces

• 1、 Moreno, Elsa,Ancizu, Saioa,Pérez-Silanes, Silvia,Torres, Enrique,Aldana, Ignacio,Monge, Antonio. "Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives". experimental part. p. 4418 - 4426. Retrieved 2010/10/19.