Technology Process of GSK series
There total 5 articles about GSK series which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-bromo-4-morpholinoquinazoline;
With
potassium acetate; bis(pinacol)diborane;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
at 117 ℃;
for 1.2h;
N-(5-bromo-2-methoxypyridine-3-yl)-2,4-difluorobenzene sulfonyl chloride;
With
potassium carbonate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; water;
at 117 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 19.17 h / 0 - 20 °C
2.1: tin(ll) chloride / ethyl acetate / 3 h / Heating / reflux
2.2: 2 h / 0 °C
3.1: pyridine / 16.25 h / 0 - 20 °C
4.1: potassium acetate; bis(pinacol)diborane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 1.2 h / 117 °C
4.2: 5 h / 117 °C
With
pyridine; potassium acetate; bis(pinacol)diborane; tin(ll) chloride;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / 16.25 h / 0 - 20 °C
2.1: potassium acetate; bis(pinacol)diborane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 1.2 h / 117 °C
2.2: 5 h / 117 °C
With
pyridine; potassium acetate; bis(pinacol)diborane;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
