[(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

Base Information

Chemical Name:[(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile
CAS No.:855310-79-1
Molecular Formula:C₃₃H₅₆N₂O₂Si₂
Molecular Weight:568.991
Hs Code.:

[(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

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Chemical Property of [(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

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Technology Process of [(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

There total 8 articles about [(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855301-94-9
6-phenyl-2,3,5,6,9,10-hexahydro-1H-4-oxa-6a-azacyclopenta[d]naphthalen-3a-ylamine

: 855310-79-1
[(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: ytterbium triflate; H₂O / tetrahydrofuran / Heating

2.1: ytterbium triflate; H₂O / tetrahydrofuran

2.2: BuLi / tetrahydrofuran / Heating

3.1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

4.1: 97 percent / imidazole / CH₂Cl₂

5.1: DIBALH / tetrahydrofuran

6.1: imidazole / dimethylformamide

With 1H-imidazole; ytterbium trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: Horner-Emmons olefination;
DOI:10.1016/j.tetlet.2005.04.019

Reference yield:

: 855310-69-9
C₁₇H₂₁NO₂

: 855310-79-1
[(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: ytterbium triflate; H₂O / tetrahydrofuran

1.2: BuLi / tetrahydrofuran / Heating

2.1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

3.1: 97 percent / imidazole / CH₂Cl₂

4.1: DIBALH / tetrahydrofuran

5.1: imidazole / dimethylformamide

With 1H-imidazole; ytterbium trifluoromethanesulfonate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Horner-Emmons olefination;
DOI:10.1016/j.tetlet.2005.04.019

Reference yield:

: 855310-73-5
C₁₉H₂₂N₂O

: 855310-79-1
[(5S,7S)-7-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-6-aza-spiro[4.5]dec-(1E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / BF₃*OEt₂ / diethyl ether; acetonitrile / -50 °C

2: 97 percent / imidazole / CH₂Cl₂

3: DIBALH / tetrahydrofuran

4: imidazole / dimethylformamide

With 1H-imidazole; boron trifluoride diethyl etherate; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2005.04.019