benzoylthioacetic acid N-phenylpiperazide

Base Information

• Chemical Name: benzoylthioacetic acid N-phenylpiperazide
• CAS No.: 86662-37-5
• Molecular Formula: C₁₉H₂₀N₂OS
• Molecular Weight: 324.447

Synonyms:

Chemical Property of benzoylthioacetic acid N-phenylpiperazide

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of benzoylthioacetic acid N-phenylpiperazide

There total 2 articles about benzoylthioacetic acid N-phenylpiperazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-phenyl-1-piperazine (92-54-6) + β-hydroxy dithiocinnamic methyl ester (17666-73-8) → benzoylthioacetic acid N-phenylpiperazide (86662-37-5)

Guidance literature:

In ethanol; for 7h; Heating;

Reference yield:

4-phenyl-1-piperazine (92-54-6) + methyl 3-oxo-3-phenylpropanedithioate (20365-21-3) → benzoylthioacetic acid N-phenylpiperazide (86662-37-5)

Guidance literature:

In ethanol; Reflux;

DOI:10.1002/ejoc.201300038

Reference yield:

benzoylthioacetic acid N-phenylpiperazide (86662-37-5) → [4-Methyl-2-(4-phenyl-piperazin-1-yl)-thiophen-3-yl]-phenyl-methanone (86662-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) acetone, reflux, 2.5 h; 2.) room temp., 3 h

2: benzene / 7 h / 70 - 80 °C

With potassium carbonate; In benzene;

DOI:10.1055/s-1983-30359

upstream raw materials:

4-phenyl-1-piperazine

β-hydroxy dithiocinnamic methyl ester

methyl 3-oxo-3-phenylpropanedithioate

Downstream raw materials:

(E)-1-Phenyl-3-(4-phenyl-piperazin-1-yl)-3-prop-2-ynylsulfanyl-propenone

3-methylthio-3-N-(N'-phenyl)piperazino-1-phenyl-2-propen-1-one

2-amino-4-N-(N'-phenyl)piperazino-6-phenylpyrimidine

[4-Methyl-2-(4-phenyl-piperazin-1-yl)-thiophen-3-yl]-phenyl-methanone

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