1H-Indole-2-carboxamide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]methyl]-N-[1-(1-methylethyl)-4-piperidinyl]-

Base Information

Chemical Name:1H-Indole-2-carboxamide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]methyl]-N-[1-(1-methylethyl)-4-piperidinyl]-
CAS No.:534573-39-2
Molecular Formula:C₂₅H₂₇ClN₄O₂S
Molecular Weight:483.034
Hs Code.:
Mol file:534573-39-2.mol

Synonyms:1-[[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl]-N-(1-propan-2-ylpiperidin-4-yl)indole-2-carboxamide;1H-Indole-2-carboxaMide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]Methyl]-N-[1-(1-Methylethyl)-4-piperidinyl]-

Suppliers and Price of 1H-Indole-2-carboxamide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]methyl]-N-[1-(1-methylethyl)-4-piperidinyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
1-[[5-(5-CHLORO-2-THIENYL)-3-ISOXAZOLYL]METHYL]-N-[1-(1-METHYLETHYL)-4-PIPERIDINYL]-1H-INDOLE-2-CARBOXAMIDE 95.00%
5MG
$ 499.35

Total 1 raw suppliers

Chemical Property of 1H-Indole-2-carboxamide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]methyl]-N-[1-(1-methylethyl)-4-piperidinyl]-

Chemical Property:

PSA：95.03000
LogP:6.17480

Purity/Quality:: 1-[[5-(5-CHLORO-2-THIENYL)-3-ISOXAZOLYL]METHYL]-N-[1-(1-METHYLETHYL)-4-PIPERIDINYL]-1H-INDOLE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-2-carboxamide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]methyl]-N-[1-(1-methylethyl)-4-piperidinyl]-

There total 12 articles about 1H-Indole-2-carboxamide, 1-[[5-(5-chloro-2-thienyl)-3-isoxazolyl]methyl]-N-[1-(1-methylethyl)-4-piperidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 127285-08-9
4-amino-1-isopropylpiperidine

: 534595-43-2
1-[5-(5-chlorothiophen-2-yl)isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid

: 534573-39-2
1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

Guidance literature:: 1-[5-(5-chlorothiophen-2-yl)isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

4-amino-1-isopropylpiperidine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm0490540

Reference yield:

: 6310-09-4
2-acetyl-5-chlorothiophene

: 534573-39-2
1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: t-BuOK / toluene / 0.17 h / 0 °C

1.2: toluene / 3 h / 20 °C

2.1: NH₂OH*HCl / ethanol / 5 h / Heating

3.1: 16 g / NaBH₄ / ethanol / 12 h / 20 °C

4.1: 77 percent / N-bromosuccinimide; PPh₃(polystyrene-bound) / CH₂Cl₂ / 1 h / 20 °C

5.1: NaH / dimethylformamide / 0.5 h / 20 °C

5.2: dimethylformamide / 1 h / 80 °C

6.1: 253 mg / lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 60 °C

7.1: Et₃N; bis(oxo-3-oxazolidinyl)phosphoryl chloride / CH₂Cl₂ / 0.5 h / 20 °C

7.2: 60 percent / CH₂Cl₂ / 16 h / 20 °C

With lithium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; PPh₃(polystyrene-bound); hydroxylamine hydrochloride; potassium tert-butylate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0490540

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 534573-39-2
1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / Na(CN)BH₃; AcOH / methanol / 16 h / 20 °C

2.1: 100 percent / HCl / methanol / 16 h / 20 °C

3.1: Et₃N; bis(oxo-3-oxazolidinyl)phosphoryl chloride / CH₂Cl₂ / 0.5 h / 20 °C

3.2: 60 percent / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm0490540