(5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone

Base Information

Chemical Name:(5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone
CAS No.:1095565-81-3
Molecular Formula:C₁₄H₂₂N₂OS
Molecular Weight:266.407
Hs Code.:
Mol file:1095565-81-3.mol

Synonyms:(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one;4(5H)-Thiazolone,2-((1S,2S,4R)-bicyclo(2.2.1)hept-2-ylamino)-5-methyl-5-(1-methylethyl)-,(5S);5S-2-(bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one;UNII-2T929W7AG8;AMG 221;

Suppliers and Price of (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
AMG-221 95.00%
5MG
$ 499.14

Total 7 raw suppliers

Chemical Property of (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone

Chemical Property:

PSA：70.25000
Density:1.35
LogP:3.08460

Purity/Quality:

99% ^*data from raw suppliers

AMG-221 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone

There total 8 articles about (5S)-2-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-ylamino]-5-methyl-5-(1-methylethyl)-4(5H)-thiazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 1095565-87-9
(S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one methanesulfonate

: 1095565-81-3,870708-16-0
AMG 221

Guidance literature:: With sodium hydroxide; water; In dichloromethane; for 1h; Purification / work up;

Reference yield: 67.7%

: 75-30-9
2-iodo-propane

: 870708-58-0
2-((1S,2S,4R)bicyclo[2.2.1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one

: 1095565-81-3,870708-16-0
AMG 221

Guidance literature:: 2-((1S,2S,4R)bicyclo[2.2.1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; N¹,N³-bis((R)-1-phenyl-2-(piperidin-1-yl)ethyl)propane-1,3-diamine; In toluene; at -15 - 22 ℃; for 1.25h;

2-iodo-propane; In toluene; at -15 - -12.5 ℃; for 0.333333h;

Reference yield: 9.0%

: 2-((+/-)-exo-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one

: 74-88-4
methyl iodide

: 1095565-81-3,870708-16-0
AMG 221

: 1155174-34-7,870708-16-0
(R)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

: 1228462-64-3,870708-16-0
(S)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

: 1228462-65-4,870708-16-0
(R)-2-((1R,2R,4S)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

Guidance literature:: 2-((+/-)-exo-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 5.5h; Inert atmosphere;
DOI:10.1021/jm100242d