tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate
CAS No.:1600511-48-5
Molecular Formula:C₁₇H₂₂BrFN₂O₄S
Molecular Weight:449.341
Hs Code.:

Synonyms:tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

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Chemical Property of tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

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Technology Process of tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

There total 8 articles about tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.1%

: ammonium molybdate

: 1600511-33-8
(R)-S-(2-(5-Bromo-2-fluorophenyl)-2-((tert-butoxy carbonyl)amino)propyl) ethanethioate

: 19481-82-4
2-bromopropionitrile

: 1600511-48-5
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

Guidance literature:: With sodium methylate; In methanol; ethanol; n-heptane; water; dihydrogen peroxide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1600511-48-5
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water

2: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

3: sodium methylate / water; ethanol; methanol; dihydrogen peroxide; n-heptane

With sodium methylate; sodium hydrogencarbonate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; water; dihydrogen peroxide;

Reference yield:

: 1313525-80-2
rac-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 1600511-48-5
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)sulfonyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

2: sodium methylate / water; ethanol; methanol; dihydrogen peroxide; n-heptane

With sodium methylate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; n-heptane; water; dihydrogen peroxide;