O-Fluoroacetophenone oxime

Base Information

• Chemical Name: O-Fluoroacetophenone oxime
• CAS No.: 364-81-8
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.156
• European Community (EC) Number: 839-656-5
• Mol file: 364-81-8.mol

Synonyms:O-Fluoroacetophenone oxime;SCHEMBL6630643;SCHEMBL14395308;GICWIGFGMGZNGL-UXBLZVDNSA-N;(1E)-1-(2-Fluorophenyl)ethanone oxime #;(E)-1-(2-fluorophenyl)ethan-1-one oxime;N-[1-(2-fluorophenyl)ethylidene]hydroxylamine;EN300-6772428

Chemical Property of O-Fluoroacetophenone oxime

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 153.058992041
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NO)C1=CC=CC=C1F
• Isomeric SMILES: C/C(=N\O)/C1=CC=CC=C1F

Technology Process of O-Fluoroacetophenone oxime

There total 4 articles about O-Fluoroacetophenone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-Fluoroacetophenone (445-27-2) → 2'-fluoroacetophenone oxime (364-81-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; at 95 ℃;

DOI:10.1021/acs.orglett.6b03155

Reference yield: 95.3%

→ 2'-fluoroacetophenone oxime (364-81-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; for 3h; Reflux;

Reference yield:

Nitroethane (79-24-3) + fluorobenzene (462-06-6) → 1-(4-fluorophenyl)ethanone oxime (329-79-3) + 2'-fluoroacetophenone oxime (364-81-8)

Guidance literature:

With trifluorormethanesulfonic acid; at 70 - 80 ℃; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)74724-1

upstream raw materials:

Nitroethane

fluorobenzene

2'-Fluoroacetophenone

Downstream raw materials:

1-(2-fluorophenyl)ethanamine

Refernces

• 1、 -. "USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS I". Page/Page column 29. . Retrieved 2021/11/06.
• 2、 Chen, Kai,Chen, Yixuan,Guan, Jianping,Tang, Kai,Wang, Zhujun,Xiang, Haoyue,Yang, Hua. "Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na". supporting information. p. 7475 - 7479. Retrieved 2021/09/08.