(R)-Methyl 2-amino-2-(4-chlorophenyl)acetate

Base Information

• Chemical Name: (R)-Methyl 2-amino-2-(4-chlorophenyl)acetate
• CAS No.: 43189-43-1
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Hs Code.: 2922499990
• European Community (EC) Number: 676-008-9
• DSSTox Substance ID: DTXSID00427718
• Nikkaji Number: J2.318.440K
• Mol file: 43189-43-1.mol

Synonyms:43189-43-1;(R)-Methyl 2-amino-2-(4-chlorophenyl)acetate;METHYL D-4-CHLOROPHENYLGLYCINATE;methyl (2R)-2-amino-2-(4-chlorophenyl)acetate;(R)-Methyl2-amino-2-(4-chlorophenyl)acetate;(R)-AMINO-(4-CHLORO-PHENYL)-ACETIC ACID METHYL ESTER;DTXSID00427718;D-4-Chlorophenylglycine Methyl Ester;MFCD07784110;4-Chloro-D-phenylglycine methyl ester;AKOS006286646;FS-2274;Methyl (2R)-amino(4-chlorophenyl)acetate;CS-0172480;Methyl(R)-2-amino-2-(4-chlorophenyl)acetate;A826209;(4-Chloro-phenylamino)-acetic acid methyl ester;hydrochloride

Chemical Property of (R)-Methyl 2-amino-2-(4-chlorophenyl)acetate

Chemical Property:

• Vapor Pressure: 0.00038mmHg at 25°C
• Boiling Point: 278.1 °C at 760 mmHg
• Flash Point: 122 °C
• PSA: 52.32000
• Density: 1.258 g/cm³
• LogP: 2.21310
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 199.0400063
• Heavy Atom Count: 13
• Complexity: 179

Purity/Quality:

97% ^*data from raw suppliers

(R)-Methyl 2-amino-2-(4-chlorophenyl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(C1=CC=C(C=C1)Cl)N
• Isomeric SMILES: COC(=O)[C@@H](C1=CC=C(C=C1)Cl)N

Technology Process of (R)-Methyl 2-amino-2-(4-chlorophenyl)acetate

There total 2 articles about (R)-Methyl 2-amino-2-(4-chlorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-(4-Chlorophenyl)glycine (6212-33-5,7292-70-8) → (R)-Amino-(4-chloro-phenyl)-acetic acid methylester (43189-43-1)

Guidance literature:

Multistep reaction; (i) H₂SO₄, (ii) acetone, (+)-tartaric acid, MeOH;

DOI:10.1039/P19760000475

Reference yield:

→ (R)-Amino-(4-chloro-phenyl)-acetic acid methylester (43189-43-1)

Guidance literature:

entspr. Racemat, Polymer (R,R)-6, Spaltung;

DOI:10.1021/ja00426a073

Reference yield: 61.0%

1'-(chloroacetyl)-spiro[isobenzofuran-1(3H),4'-piperidine] (154773-15-6) + (R)-Amino-(4-chloro-phenyl)-acetic acid methylester (43189-43-1) → Methyl (2R)-(4-chlorophenyl){[2-oxo-2-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)ethyl]amino}acetate (1039167-39-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃;

upstream raw materials:

methanol

2-(4-Chlorophenyl)glycine

Downstream raw materials:

(R)-2-amino-2-(4-chlorophenyl)acetic acid

Methyl (2R)-(4-chlorophenyl){[2-oxo-2-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)ethyl]amino}acetate

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