1-Azidohexaethylene Glycol

Base Information

• Chemical Name: 1-Azidohexaethylene Glycol
• CAS No.: 86770-68-5
• Molecular Formula: C₁₀H₂₁N₃O₅
• Molecular Weight: 263.294
• Hs Code.: 29051990
• Mol file: 86770-68-5.mol

Synonyms:2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol;

Chemical Property of 1-Azidohexaethylene Glycol

Chemical Property:

• Refractive Index: 1.4650-1.4690
• Flash Point: 100℃
• PSA: 106.90000
• LogP: -0.19184
• Storage Temp.: 0-10°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

14-Azido-3,6,9,12-tetraoxatetradecanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 14-Azido-3,6,9,12-tetraoxatetrsdecanol is a polyethyleneglycol (PEG) derivative used in the preparation of diverse targeted microenvironmental sensors. As a polyethyleneglycol (PEG) derivative, 14-Azido-3,6,9,12-tetraoxatetradecanol can be used in the preparation of diverse targeted microenvironmental sensors. 1-Azidohexaethylene Glycol is used to prepare heparin-like antithrombotics having perphosphorylated thrombin binding domains.
• Description: Azido-PEG5-alcohol is a water soluble PEG linker containing an azide (N3) and a terminal hydroxyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of 1-Azidohexaethylene Glycol

There total 9 articles about 1-Azidohexaethylene Glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate (155130-15-7) → 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5)

Guidance literature:

With sodium azide; In ethanol; Reflux;

Reference yield: 91.0%

Pentaethylene glycol (4792-15-8) → 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5)

Guidance literature:

With sodium azide; In acetonitrile; for 12h; Reflux;

DOI:10.1021/acs.jmedchem.7b01220

Reference yield: 90.0%

→ 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 45 ℃;

upstream raw materials:

14-{(methylsulfonyl)oxy}-3,6,9,12-tetraoxatetradecanol

Pentaethylene glycol

2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

14-azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate

Downstream raw materials:

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid