1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone

Base Information

Chemical Name:1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone
CAS No.:97760-76-4
Molecular Formula:C9H7ClF3NO
Molecular Weight:237.609
Hs Code.:2922399090
DSSTox Substance ID:DTXSID70538087
Wikidata:Q72435017
Mol file:97760-76-4.mol

Synonyms:97760-76-4;1-(4-AMINO-3-CHLORO-5-(TRIFLUOROMETHYL)PHENYL)ETHANONE;4'-amino-3'-chloro-5'-(trifluoromethyl)acetophenone;1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone;4-Amino-3-chloro-5-(trifluoromethyl)acetophenone;Ethanone, 1-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-;4'-AMINO-3'-CHLORO-5'-TRIFLUOROMETHYLACETOPHENONE;4'-AMINO-3'-CHLORO-5'-(TRIFLUOROMETHYL)ACETOPHENON;MFCD09907719;SCHEMBL5166345;DTXSID70538087;GVPVKKWXJXESIC-UHFFFAOYSA-N;BCP17332;CL8660;AKOS015841054;DS-17663;A845747;1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethan-1-one;1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone

Suppliers and Price of 1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
50mg
$ 95.00

TRC
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
100mg
$ 155.00

TRC
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
1g
$ 1230.00

Medical Isotopes, Inc.
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
100 mg
$ 890.00

Crysdot
1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone 95+%
5g
$ 161.00

Chemenu
1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone 95%
10g
$ 410.00

Chemenu
1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone 95%
5g
$ 273.00

Biosynth Carbosynth
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
2 g
$ 200.00

Biosynth Carbosynth
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
1 g
$ 120.00

Biosynth Carbosynth
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone
500 mg
$ 75.00

Total 33 raw suppliers

Chemical Property of 1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone

Chemical Property:

Melting Point:132-134 °C
Boiling Point:288.415 °C at 760 mmHg
Flash Point:128.229 °C
PSA：43.09000
Density:1.408 g/cm³
LogP:3.72480
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:237.0168260
Heavy Atom Count:15
Complexity:256

Purity/Quality:

99% ^*data from raw suppliers

1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]ethanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC(=C(C(=C1)Cl)N)C(F)(F)F

Technology Process of 1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone

There total 3 articles about 1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 63498-15-7
4-amino-3-chloro-5-trifluoromethyl-benzoyl chloride

: 105-53-3
diethyl malonate

: 97760-76-4
4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone

Guidance literature:: With ethanol; magnesium; tetrachloromethane; In tetrahydrofuran; Heating / reflux;

diethyl malonate; In tetrahydrofuran; ethanol; for 3h; Heating / reflux;

4-amino-3-chloro-5-trifluoromethyl-benzoyl chloride; In tetrahydrofuran; ethanol; for 2.5h; Heating / reflux;

Reference yield:

: 95656-52-3
4-amino-3-chloro-5-(trifluoromethyl)benzoic acid

: 97760-76-4
4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: magnesium ethylate / tetrahydrofuran; ethanol / 2 h / Reflux

2.2: Reflux

With thionyl chloride; magnesium ethylate; In tetrahydrofuran; ethanol;
DOI:10.1002/jlcr.1796