95656-52-3

Basic information

• Product Name: 4-amino-3-chloro-5-trifluoromethyl-benzoic acid
• Synonyms: 4-amino-3-chloro-5-trifluoromethyl-benzoic acid
• CAS NO: 95656-52-3
• Molecular Formula: C₈H₅ClF₃NO₂
• Molecular Weight: 239.58
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 95656-52-3.mol

Chemical Properties

• Melting Point: 228-236 ºC
• Boiling Point: 311.7 °C at 760 mmHg
• Flash Point: 142.3 °C
• Appearance: /
• Density: 1.600
• Vapor Pressure: 0.000238mmHg at 25°C
• Refractive Index: 1.544
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 4-amino-3-chloro-5-trifluoromethyl-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-3-chloro-5-trifluoromethyl-benzoic acid(95656-52-3)
• EPA Substance Registry System: 4-amino-3-chloro-5-trifluoromethyl-benzoic acid(95656-52-3)

Safety Data

• Hazardous Substances Data: 95656-52-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Mabuterol intermediate.

InChI:InChI=1/C8H5ClF3NO2/c9-5-2-3(7(14)15)1-4(6(5)13)8(10,11)12/h1-2H,13H2,(H,14,15)

Upstream product

• 88-17-5 2-(trifluoromethyl)benzenamine 
• 175277-96-0 N-(4-cyano-2-(trifluoromethyl)phenyl)acetamide 
• 97760-97-9 4-iodo-2-(trifluoromethyl)aniline 
• 400-76-0 4-amino-3-(trifluoromethyl)benzoic acid 
• 97760-98-0 N-(4-iodo-2-(trifluoromethyl)phenyl)acetamide 

Downstream Products

• 97776-04-0 diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzoyl)-malonate 
• 1476760-57-2 methyl 4-amino-3-chloro-5-(trifluoromethyl)benzoate 
• 848130-79-0 2-chloro-4-oxiran-2-yl-6-(trifluoromethyl)aniline 
• 97760-87-7 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-bromoethanone 
• 97760-76-4 4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone 
• 63498-15-7 4-amino-3-chloro-5-trifluoromethyl-benzoyl chloride 

Relevant articles and documents

Derivative of n-[phenyl(piperidin-2-yl)methyl]benzamide, the preparation method thereof and application of same in therapeutics

Compound of general formula (I) in which A represents either a group of formula N—R1 in which R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a phenylalkyl group, an alkenyl group or an alkynyl group, or a group of

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.